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Forkhead box K2

PDB rendering based on 1jxs.
Available structures
1jxs, 2c6y
Symbols FOXK2; ILF; ILF-1; ILF1
External IDs OMIM147685 MGI1916087 HomoloGene18748 GeneCards: FOXK2 Gene
RNA expression pattern
PBB GE FOXK2 203064 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3607 68837
Ensembl ENSG00000141568 n/a
UniProt Q01167 n/a
RefSeq (mRNA) XM_001134363 XM_126489
RefSeq (protein) XP_001134363 XP_126489
Location (UCSC) Chr 17:
78.07 - 78.15 Mb
PubMed search [1] [2]

Forkhead box protein K2 is a protein that in humans is encoded by the FOXK2 gene.[1][2]

The protein encoded by this gene contains a fork head DNA binding domain. This protein can bind to the purine-rich motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2) promoter. It may be involved in the regulation of viral and cellular promoter elements.[2]


Further reading

  • Li C, Lusis AJ, Sparkes R, et al. (1992). "Characterization and chromosomal mapping of the gene encoding the cellular DNA binding protein ILF.". Genomics 13 (3): 665–71. doi:10.1016/0888-7543(92)90139-J. PMID 1339390.  
  • Li C, Lai CF, Sigman DS, Gaynor RB (1991). "Cloning of a cellular factor, interleukin binding factor, that binds to NFAT-like motifs in the human immunodeficiency virus long terminal repeat.". Proc. Natl. Acad. Sci. U.S.A. 88 (17): 7739–43. doi:10.1073/pnas.88.17.7739. PMID 1909027.  
  • Nirula A, Moore DJ, Gaynor RB (1997). "Constitutive binding of the transcription factor interleukin-2 (IL-2) enhancer binding factor to the IL-2 promoter.". J. Biol. Chem. 272 (12): 7736–45. doi:10.1074/jbc.272.12.7736. PMID 9065434.  
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.  
  • Liu PP, Chen YC, Li C, et al. (2003). "Solution structure of the DNA-binding domain of interleukin enhancer binding factor 1 (FOXK1a).". Proteins 49 (4): 543–53. doi:10.1002/prot.10227. PMID 12402362.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Tsai KL, Huang CY, Chang CH, et al. (2006). "Crystal structure of the human FOXK1a-DNA complex and its implications on the diverse binding specificity of winged helix/forkhead proteins.". J. Biol. Chem. 281 (25): 17400–9. doi:10.1074/jbc.M600478200. PMID 16624804.  
  • Zody MC, Garber M, Adams DJ, et al. (2006). "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.". Nature 440 (7087): 1045–9. doi:10.1038/nature04689. PMID 16625196.  
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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