The Full Wiki

More info on FOXN3

FOXN3: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

edit
Checkpoint suppressor 1
Identifiers
Symbols CHES1; C14orf116; FOXN3; PRO1635
External IDs OMIM602628 MGI1918625 HomoloGene3809 GeneCards: CHES1 Gene
RNA expression pattern
PBB GE CHES1 205022 s at tn.png
PBB GE CHES1 205021 s at tn.png
PBB GE CHES1 218031 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1112 71375
Ensembl ENSG00000053254 ENSMUSG00000033713
UniProt O00409 Q499D0
RefSeq (mRNA) NM_005197 NM_183186
RefSeq (protein) NP_005188 NP_899009
Location (UCSC) Chr 14:
88.69 - 88.95 Mb
Chr 12:
99.6 - 99.85 Mb
PubMed search [1] [2]

Forkhead box protein N3 is a protein that in humans is encoded by the FOXN3 gene.[1][2]

This gene is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway. Alternative splicing is observed at the locus, resulting in distinct isoforms.[2]

Contents

See also

References

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Field LL, Tobias R, Thomson G, Plon S (1996). "Susceptibility to insulin-dependent diabetes mellitus maps to a locus (IDDM11) on human chromosome 14q24.3-q31.". Genomics 33 (1): 1–8. doi:10.1006/geno.1996.0153. PMID 8617492.  
  • Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  
  • Yu Y, Zhang C, Zhou G, et al. (2001). "Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs.". Genome Res. 11 (8): 1392–403. doi:10.1101/gr.175501. PMID 11483580.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14.". Nature 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMID 15231747.  
  • Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Scott KL, Plon SE (2005). "CHES1/FOXN3 interacts with Ski-interacting protein and acts as a transcriptional repressor.". Gene 359: 119–26. doi:10.1016/j.gene.2005.06.014. PMID 16102918.  
  • Busygina V, Kottemann MC, Scott KL, et al. (2007). "Multiple endocrine neoplasia type 1 interacts with forkhead transcription factor CHES1 in DNA damage response.". Cancer Res. 66 (17): 8397–403. doi:10.1158/0008-5472.CAN-06-0061. PMID 16951149.  
  • Katoh H, Ojima H, Kokubu A, et al. (2007). "Genetically distinct and clinically relevant classification of hepatocellular carcinoma: putative therapeutic targets.". Gastroenterology 133 (5): 1475–86. doi:10.1053/j.gastro.2007.08.038. PMID 17983802.  

External links

Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message