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Forkhead box O1
External IDs OMIM136533 MGI1890077 HomoloGene1527 GeneCards: FOXO1 Gene
RNA expression pattern
PBB GE FOXO1A 202724 s at tn.png
PBB GE FOXO1A 202723 s at tn.png
More reference expression data
Species Human Mouse
Entrez 2308 56458
Ensembl ENSG00000150907 ENSMUSG00000044167
UniProt Q12778 Q8BPP2
RefSeq (mRNA) NM_002015 NM_019739
RefSeq (protein) NP_002006 NP_062713
Location (UCSC) Chr 13:
40.03 - 40.14 Mb
Chr 3:
52.36 - 52.44 Mb
PubMed search [1] [2]

Forkhead box O1 also known as FOXO1 is a protein which in humans is encoded by the FOXO1 gene.[1]



FOXO1 belongs to the forkhead family of transcription factors which are characterized by a distinct fork head domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation.[2]

Clinical signficance

Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma.[1][3]


FOXO1 has been shown to interact with TSC2,[4] Androgen receptor,[5] Estrogen receptor alpha[6] and CREB binding protein.[7]


  1. ^ a b Galili N, Davis RJ, Fredericks WJ, Mukhopadhyay S, Rauscher FJ, Emanuel BS, Rovera G, Barr FG (November 1993). "Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma". Nat. Genet. 5 (3): 230–5. doi:10.1038/ng1193-230. PMID 8275086.  
  2. ^ "Entrez Gene: FOXO1 forkhead box O1 (rhabdomyosarcoma)".  
  3. ^ Linardic CM (October 2008). "PAX3-FOXO1 fusion gene in rhabdomyosarcoma". Cancer Lett. 270 (1): 10–8. doi:10.1016/j.canlet.2008.03.035. PMID 18457914.  
  4. ^ Cao, Yongheng; Kamioka Yuji, Yokoi Norihide, Kobayashi Toshiyuki, Hino Okio, Onodera Masafumi, Mochizuki Naoki, Nakae Jun (Dec. 2006). "Interaction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 S6K pathway". J. Biol. Chem. (United States) 281 (52): 40242–51. doi:10.1074/jbc.M608116200. ISSN 0021-9258. PMID 17077083.  
  5. ^ Li, Pengfei; Lee Heehyoung, Guo Shaodong, Unterman Terry G, Jenster Guido, Bai Wenlong (Jan. 2003). "AKT-independent protection of prostate cancer cells from apoptosis mediated through complex formation between the androgen receptor and FKHR". Mol. Cell. Biol. (United States) 23 (1): 104–18. ISSN 0270-7306. PMID 12482965.  
  6. ^ Schuur, E R; Loktev A V, Sharma M, Sun Z, Roth R A, Weigel R J (Sep. 2001). "Ligand-dependent interaction of estrogen receptor-alpha with members of the forkhead transcription factor family". J. Biol. Chem. (United States) 276 (36): 33554–60. doi:10.1074/jbc.M105555200. ISSN 0021-9258. PMID 11435445.  
  7. ^ Nasrin, N; Ogg S, Cahill C M, Biggs W, Nui S, Dore J, Calvo D, Shi Y, Ruvkun G, Alexander-Bridges M C (Sep. 2000). "DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (19): 10412–7. doi:10.1073/pnas.190326997. ISSN 0027-8424. PMID 10973497.  

Further reading

  • Sublett JE, Jeon IS, Shapiro DN (1995). "The alveolar rhabdomyosarcoma PAX3/FKHR fusion protein is a transcriptional activator.". Oncogene 11 (3): 545–52. PMID 7630639.  
  • Fredericks WJ, Galili N, Mukhopadhyay S, et al. (1995). "The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3.". Mol. Cell. Biol. 15 (3): 1522–35. PMID 7862145.  
  • Galili N, Davis RJ, Fredericks WJ, et al. (1994). "Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma.". Nat. Genet. 5 (3): 230–5. doi:10.1038/ng1193-230. PMID 8275086.  
  • Scheidler S, Fredericks WJ, Rauscher FJ, et al. (1996). "The hybrid PAX3-FKHR fusion protein of alveolar rhabdomyosarcoma transforms fibroblasts in culture.". Proc. Natl. Acad. Sci. U.S.A. 93 (18): 9805–9. PMID 8790412.  
  • Anderson MJ, Viars CS, Czekay S, et al. (1998). "Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily.". Genomics 47 (2): 187–99. doi:10.1006/geno.1997.5122. PMID 9479491.  
  • Tang ED, Nuñez G, Barr FG, Guan KL (1999). "Negative regulation of the forkhead transcription factor FKHR by Akt.". J. Biol. Chem. 274 (24): 16741–6. PMID 10358014.  
  • Rena G, Guo S, Cichy SC, et al. (1999). "Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B.". J. Biol. Chem. 274 (24): 17179–83. PMID 10358075.  
  • Medema RH, Kops GJ, Bos JL, Burgering BM (2000). "AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1.". Nature 404 (6779): 782–7. doi:10.1038/35008115. PMID 10783894.  
  • Margue CM, Bernasconi M, Barr FG, Schäfer BW (2000). "Transcriptional modulation of the anti-apoptotic protein BCL-XL by the paired box transcription factors PAX3 and PAX3/FKHR.". Oncogene 19 (25): 2921–9. doi:10.1038/sj.onc.1203607. PMID 10871843.  
  • Nasrin N, Ogg S, Cahill CM, et al. (2000). "DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells.". Proc. Natl. Acad. Sci. U.S.A. 97 (19): 10412–7. doi:10.1073/pnas.190326997. PMID 10973497.  
  • Jackson JG, Kreisberg JI, Koterba AP, et al. (2000). "Phosphorylation and nuclear exclusion of the forkhead transcription factor FKHR after epidermal growth factor treatment in human breast cancer cells.". Oncogene 19 (40): 4574–81. doi:10.1038/sj.onc.1203825. PMID 11030146.  
  • Rena G, Prescott AR, Guo S, et al. (2001). "Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targeting.". Biochem. J. 354 (Pt 3): 605–12. PMID 11237865.  
  • Woods YL, Rena G, Morrice N, et al. (2001). "The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site.". Biochem. J. 355 (Pt 3): 597–607. PMID 11311120.  
  • Zhao HH, Herrera RE, Coronado-Heinsohn E, et al. (2001). "Forkhead homologue in rhabdomyosarcoma functions as a bifunctional nuclear receptor-interacting protein with both coactivator and corepressor functions.". J. Biol. Chem. 276 (30): 27907–12. doi:10.1074/jbc.M104278200. PMID 11353774.  
  • Schuur ER, Loktev AV, Sharma M, et al. (2001). "Ligand-dependent interaction of estrogen receptor-alpha with members of the forkhead transcription factor family.". J. Biol. Chem. 276 (36): 33554–60. doi:10.1074/jbc.M105555200. PMID 11435445.  
  • Patel S, Lochhead PA, Rena G, Sutherland C (2001). "Antagonistic effects of phorbol esters on insulin regulation of insulin-like growth factor-binding protein-1 (IGFBP-1) but not glucose-6-phosphatase gene expression.". Biochem. J. 359 (Pt 3): 611–9. PMID 11672436.  
  • Ayalon D, Glaser T, Werner H (2002). "Transcriptional regulation of IGF-I receptor gene expression by the PAX3-FKHR oncoprotein.". Growth Horm. IGF Res. 11 (5): 289–97. doi:10.1054/ghir.2001.0244. PMID 11735247.  
  • Christian M, Zhang X, Schneider-Merck T, et al. (2002). "Cyclic AMP-induced forkhead transcription factor, FKHR, cooperates with CCAAT/enhancer-binding protein beta in differentiating human endometrial stromal cells.". J. Biol. Chem. 277 (23): 20825–32. doi:10.1074/jbc.M201018200. PMID 11893744.  
  • Rena G, Woods YL, Prescott AR, et al. (2002). "Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion.". EMBO J. 21 (9): 2263–71. doi:10.1093/emboj/21.9.2263. PMID 11980723.  
  • Sorensen PH, Lynch JC, Qualman SJ, et al. (2002). "PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: a report from the children's oncology group.". J. Clin. Oncol. 20 (11): 2672–9. PMID 12039929.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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