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Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7

PDB rendering based on 1e17.
Available structures
1e17
Identifiers
Symbols MLLT7; AFX; AFX1; FOXO4; MGC120490
External IDs OMIM300033 MGI1891915 HomoloGene4342 GeneCards: MLLT7 Gene
RNA expression pattern
PBB GE MLLT7 205451 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4303 54601
Ensembl ENSG00000184481 ENSMUSG00000042903
UniProt P98177 Q9WVH3
RefSeq (mRNA) NM_005938 XM_983128
RefSeq (protein) NP_005929 XP_988222
Location (UCSC) Chr X:
70.23 - 70.24 Mb
Chr X:
97.46 - 97.46 Mb
PubMed search [1] [2]

Forkhead box protein O4 is a protein that in humans is encoded by the FOXO4 gene.[1][2]

Contents

See also

Interactions

FOXO4 has been shown to interact with PIN1[3] and Mdm2.[4]

References

  1. ^ Parry P, Wei Y, Evans G (Feb 1995). "Cloning and characterization of the t(X;11) breakpoint from a leukemic cell line identify a new member of the forkhead gene family". Genes Chromosomes Cancer 11 (2): 79–84. PMID 7529552.  
  2. ^ "Entrez Gene: MLLT7 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4303.  
  3. ^ Brenkman, Arjan B; de Keizer Peter L J, van den Broek Niels J F, van der Groep Petra, van Diest Paul J, van der Horst Armando, Smits Alida M M, Burgering Boudewijn M T (Sep. 2008). "The peptidyl-isomerase Pin1 regulates p27kip1 expression through inhibition of Forkhead box O tumor suppressors". Cancer Res. (United States) 68 (18): 7597–605. doi:10.1158/0008-5472.CAN-08-1059. PMID 18794148.  
  4. ^ Brenkman, Arjan B; de Keizer Peter L J, van den Broek Niels J F, Jochemsen A G, Burgering Boudewijn M Th (2008). "Mdm2 induces mono-ubiquitination of FOXO4". PLoS ONE (United States) 3 (7): e2819. doi:10.1371/journal.pone.0002819. PMID 18665269.  

Further reading

  • Borkhardt A, Repp R, Haas OA, et al. (1997). "Cloning and characterization of AFX, the gene that fuses to MLL in acute leukemias with a t(X;11)(q13;q23).". Oncogene 14 (2): 195–202. doi:10.1038/sj.onc.1200814. PMID 9010221.  
  • Peters U, Haberhausen G, Kostrzewa M, et al. (1997). "AFX1 and p54nrb: fine mapping, genomic structure, and exclusion as candidate genes of X-linked dystonia parkinsonism.". Hum. Genet. 100 (5-6): 569–72. doi:10.1007/s004390050553. PMID 9341872.  
  • Kops GJ, de Ruiter ND, De Vries-Smits AM, et al. (1999). "Direct control of the Forkhead transcription factor AFX by protein kinase B.". Nature 398 (6728): 630–4. doi:10.1038/19328. PMID 10217147.  
  • Takaishi H, Konishi H, Matsuzaki H, et al. (1999). "Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B.". Proc. Natl. Acad. Sci. U.S.A. 96 (21): 11836–41. doi:10.1073/pnas.96.21.11836. PMID 10518537.  
  • Medema RH, Kops GJ, Bos JL, Burgering BM (2000). "AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1.". Nature 404 (6779): 782–7. doi:10.1038/35008115. PMID 10783894.  
  • Furuyama T, Nakazawa T, Nakano I, Mori N (2001). "Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues.". Biochem. J. 349 (Pt 2): 629–34. doi:10.1042/0264-6021:3490629. PMID 10880363.  
  • Weigelt J, Climent I, Dahlman-Wright K, Wikström M (2000). "1H, 13C and 15N resonance assignments of the DNA binding domain of the human forkhead transcription factor AFX.". J. Biomol. NMR 17 (2): 181–2. doi:10.1023/A:1008358816478. PMID 10921784.  
  • Nasrin N, Ogg S, Cahill CM, et al. (2000). "DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells.". Proc. Natl. Acad. Sci. U.S.A. 97 (19): 10412–7. doi:10.1073/pnas.190326997. PMID 10973497.  
  • Brownawell AM, Kops GJ, Macara IG, Burgering BM (2001). "Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX.". Mol. Cell. Biol. 21 (10): 3534–46. doi:10.1128/MCB.21.10.3534-3546.2001. PMID 11313479.  
  • Weigelt J, Climent I, Dahlman-Wright K, Wikström M (2001). "Solution structure of the DNA binding domain of the human forkhead transcription factor AFX (FOXO4).". Biochemistry 40 (20): 5861–9. doi:10.1021/bi001663w. PMID 11352721.  
  • Schuur ER, Loktev AV, Sharma M, et al. (2001). "Ligand-dependent interaction of estrogen receptor-alpha with members of the forkhead transcription factor family.". J. Biol. Chem. 276 (36): 33554–60. doi:10.1074/jbc.M105555200. PMID 11435445.  
  • De Ruiter ND, Burgering BM, Bos JL (2001). "Regulation of the Forkhead transcription factor AFX by Ral-dependent phosphorylation of threonines 447 and 451.". Mol. Cell. Biol. 21 (23): 8225–35. doi:10.1128/MCB.21.23.8225-8235.2001. PMID 11689711.  
  • Tang TT, Dowbenko D, Jackson A, et al. (2002). "The forkhead transcription factor AFX activates apoptosis by induction of the BCL-6 transcriptional repressor.". J. Biol. Chem. 277 (16): 14255–65. doi:10.1074/jbc.M110901200. PMID 11777915.  
  • Yang Z, Whelan J, Babb R, Bowen BR (2002). "An mRNA splice variant of the AFX gene with altered transcriptional activity.". J. Biol. Chem. 277 (10): 8068–75. doi:10.1074/jbc.M106091200. PMID 11779849.  
  • Kops GJ, Medema RH, Glassford J, et al. (2002). "Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors.". Mol. Cell. Biol. 22 (7): 2025–36. doi:10.1128/MCB.22.7.2025-2036.2002. PMID 11884591.  
  • So CW, Cleary ML (2002). "MLL-AFX requires the transcriptional effector domains of AFX to transform myeloid progenitors and transdominantly interfere with forkhead protein function.". Mol. Cell. Biol. 22 (18): 6542–52. doi:10.1128/MCB.22.18.6542-6552.2002. PMID 12192052.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Tang TT, Lasky LA (2003). "The forkhead transcription factor FOXO4 induces the down-regulation of hypoxia-inducible factor 1 alpha by a von Hippel-Lindau protein-independent mechanism.". J. Biol. Chem. 278 (32): 30125–35. doi:10.1074/jbc.M302042200. PMID 12761217.  
  • Crossley LJ (2003). "Neutrophil activation by fMLP regulates FOXO (forkhead) transcription factors by multiple pathways, one of which includes the binding of FOXO to the survival factor Mcl-1.". J. Leukoc. Biol. 74 (4): 583–92. doi:10.1189/jlb.0103020. PMID 12960271.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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