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FOXO4: Wikis


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Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7

PDB rendering based on 1e17.
Available structures
Symbols MLLT7; AFX; AFX1; FOXO4; MGC120490
External IDs OMIM300033 MGI1891915 HomoloGene4342 GeneCards: MLLT7 Gene
RNA expression pattern
PBB GE MLLT7 205451 at tn.png
More reference expression data
Species Human Mouse
Entrez 4303 54601
Ensembl ENSG00000184481 ENSMUSG00000042903
UniProt P98177 Q9WVH3
RefSeq (mRNA) NM_005938 XM_983128
RefSeq (protein) NP_005929 XP_988222
Location (UCSC) Chr X:
70.23 - 70.24 Mb
Chr X:
97.46 - 97.46 Mb
PubMed search [1] [2]

Forkhead box protein O4 is a protein that in humans is encoded by the FOXO4 gene.[1][2]


See also


FOXO4 has been shown to interact with PIN1[3] and Mdm2.[4]


  1. ^ Parry P, Wei Y, Evans G (Feb 1995). "Cloning and characterization of the t(X;11) breakpoint from a leukemic cell line identify a new member of the forkhead gene family". Genes Chromosomes Cancer 11 (2): 79–84. PMID 7529552.  
  2. ^ "Entrez Gene: MLLT7 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7".  
  3. ^ Brenkman, Arjan B; de Keizer Peter L J, van den Broek Niels J F, van der Groep Petra, van Diest Paul J, van der Horst Armando, Smits Alida M M, Burgering Boudewijn M T (Sep. 2008). "The peptidyl-isomerase Pin1 regulates p27kip1 expression through inhibition of Forkhead box O tumor suppressors". Cancer Res. (United States) 68 (18): 7597–605. doi:10.1158/0008-5472.CAN-08-1059. PMID 18794148.  
  4. ^ Brenkman, Arjan B; de Keizer Peter L J, van den Broek Niels J F, Jochemsen A G, Burgering Boudewijn M Th (2008). "Mdm2 induces mono-ubiquitination of FOXO4". PLoS ONE (United States) 3 (7): e2819. doi:10.1371/journal.pone.0002819. PMID 18665269.  

Further reading

  • Borkhardt A, Repp R, Haas OA, et al. (1997). "Cloning and characterization of AFX, the gene that fuses to MLL in acute leukemias with a t(X;11)(q13;q23).". Oncogene 14 (2): 195–202. doi:10.1038/sj.onc.1200814. PMID 9010221.  
  • Peters U, Haberhausen G, Kostrzewa M, et al. (1997). "AFX1 and p54nrb: fine mapping, genomic structure, and exclusion as candidate genes of X-linked dystonia parkinsonism.". Hum. Genet. 100 (5-6): 569–72. doi:10.1007/s004390050553. PMID 9341872.  
  • Kops GJ, de Ruiter ND, De Vries-Smits AM, et al. (1999). "Direct control of the Forkhead transcription factor AFX by protein kinase B.". Nature 398 (6728): 630–4. doi:10.1038/19328. PMID 10217147.  
  • Takaishi H, Konishi H, Matsuzaki H, et al. (1999). "Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B.". Proc. Natl. Acad. Sci. U.S.A. 96 (21): 11836–41. doi:10.1073/pnas.96.21.11836. PMID 10518537.  
  • Medema RH, Kops GJ, Bos JL, Burgering BM (2000). "AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1.". Nature 404 (6779): 782–7. doi:10.1038/35008115. PMID 10783894.  
  • Furuyama T, Nakazawa T, Nakano I, Mori N (2001). "Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues.". Biochem. J. 349 (Pt 2): 629–34. doi:10.1042/0264-6021:3490629. PMID 10880363.  
  • Weigelt J, Climent I, Dahlman-Wright K, Wikström M (2000). "1H, 13C and 15N resonance assignments of the DNA binding domain of the human forkhead transcription factor AFX.". J. Biomol. NMR 17 (2): 181–2. doi:10.1023/A:1008358816478. PMID 10921784.  
  • Nasrin N, Ogg S, Cahill CM, et al. (2000). "DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells.". Proc. Natl. Acad. Sci. U.S.A. 97 (19): 10412–7. doi:10.1073/pnas.190326997. PMID 10973497.  
  • Brownawell AM, Kops GJ, Macara IG, Burgering BM (2001). "Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX.". Mol. Cell. Biol. 21 (10): 3534–46. doi:10.1128/MCB.21.10.3534-3546.2001. PMID 11313479.  
  • Weigelt J, Climent I, Dahlman-Wright K, Wikström M (2001). "Solution structure of the DNA binding domain of the human forkhead transcription factor AFX (FOXO4).". Biochemistry 40 (20): 5861–9. doi:10.1021/bi001663w. PMID 11352721.  
  • Schuur ER, Loktev AV, Sharma M, et al. (2001). "Ligand-dependent interaction of estrogen receptor-alpha with members of the forkhead transcription factor family.". J. Biol. Chem. 276 (36): 33554–60. doi:10.1074/jbc.M105555200. PMID 11435445.  
  • De Ruiter ND, Burgering BM, Bos JL (2001). "Regulation of the Forkhead transcription factor AFX by Ral-dependent phosphorylation of threonines 447 and 451.". Mol. Cell. Biol. 21 (23): 8225–35. doi:10.1128/MCB.21.23.8225-8235.2001. PMID 11689711.  
  • Tang TT, Dowbenko D, Jackson A, et al. (2002). "The forkhead transcription factor AFX activates apoptosis by induction of the BCL-6 transcriptional repressor.". J. Biol. Chem. 277 (16): 14255–65. doi:10.1074/jbc.M110901200. PMID 11777915.  
  • Yang Z, Whelan J, Babb R, Bowen BR (2002). "An mRNA splice variant of the AFX gene with altered transcriptional activity.". J. Biol. Chem. 277 (10): 8068–75. doi:10.1074/jbc.M106091200. PMID 11779849.  
  • Kops GJ, Medema RH, Glassford J, et al. (2002). "Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors.". Mol. Cell. Biol. 22 (7): 2025–36. doi:10.1128/MCB.22.7.2025-2036.2002. PMID 11884591.  
  • So CW, Cleary ML (2002). "MLL-AFX requires the transcriptional effector domains of AFX to transform myeloid progenitors and transdominantly interfere with forkhead protein function.". Mol. Cell. Biol. 22 (18): 6542–52. doi:10.1128/MCB.22.18.6542-6552.2002. PMID 12192052.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Tang TT, Lasky LA (2003). "The forkhead transcription factor FOXO4 induces the down-regulation of hypoxia-inducible factor 1 alpha by a von Hippel-Lindau protein-independent mechanism.". J. Biol. Chem. 278 (32): 30125–35. doi:10.1074/jbc.M302042200. PMID 12761217.  
  • Crossley LJ (2003). "Neutrophil activation by fMLP regulates FOXO (forkhead) transcription factors by multiple pathways, one of which includes the binding of FOXO to the survival factor Mcl-1.". J. Leukoc. Biol. 74 (4): 583–92. doi:10.1189/jlb.0103020. PMID 12960271.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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