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Forkhead box P1
Symbols FOXP1; 12CC4; FLJ23741; HSPC215; MGC12942; MGC88572; MGC99551; QRF1; hFKH1B
External IDs OMIM605515 MGI1914004 HomoloGene13092 GeneCards: FOXP1 Gene
Species Human Mouse
Entrez 27086 108655
Ensembl ENSG00000114861 ENSMUSG00000030067
UniProt Q9H334 Q6P221
RefSeq (mRNA) NM_001012505 NM_053202
RefSeq (protein) NP_001012523 NP_444432
Location (UCSC) Chr 3:
71.09 - 71.72 Mb
Chr 6:
98.9 - 99.23 Mb
PubMed search [1] [2]

FOXP1 ("forkhead box P1") is a gene that is necessary for the proper development of the brain and lung in mammals. It is a member of the large FOX family of transcription factors.

This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms.[1]


See also


Further reading

  • Katoh M, Katoh M (2005). "Human FOX gene family (Review).". Int. J. Oncol. 25 (5): 1495–500. PMID 15492844.  
  • Li C, Tucker PW (1994). "DNA-binding properties and secondary structural model of the hepatocyte nuclear factor 3/fork head domain.". Proc. Natl. Acad. Sci. U.S.A. 90 (24): 11583–7. doi:10.1073/pnas.90.24.11583. PMID 8265594.  
  • Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMID 11042152.  
  • Banham AH, Beasley N, Campo E, et al. (2002). "The FOXP1 winged helix transcription factor is a novel candidate tumor suppressor gene on chromosome 3p.". Cancer Res. 61 (24): 8820–9. PMID 11751404.  
  • Wolska MK, Bukowski K, Jakubczak A (2002). "[Occurrence of beta-lactamase type ESBL and IBL in Pseudomonas aeruginosa rods]". Medycyna doświadczalna i mikrobiologia 53 (1): 45–51. PMID 11757404.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Wang B, Lin D, Li C, Tucker P (2003). "Multiple domains define the expression and regulatory properties of Foxp1 forkhead transcriptional repressors.". J. Biol. Chem. 278 (27): 24259–68. doi:10.1074/jbc.M207174200. PMID 12692134.  
  • Li S, Weidenfeld J, Morrisey EE (2004). "Transcriptional and DNA binding activity of the Foxp1/2/4 family is modulated by heterotypic and homotypic protein interactions.". Mol. Cell. Biol. 24 (2): 809–22. doi:10.1128/MCB.24.2.809-822.2004. PMID 14701752.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Teramitsu I, Kudo LC, London SE, et al. (2004). "Parallel FoxP1 and FoxP2 expression in songbird and human brain predicts functional interaction.". J. Neurosci. 24 (13): 3152–63. doi:10.1523/JNEUROSCI.5589-03.2004. PMID 15056695.  
  • Fox SB, Brown P, Han C, et al. (2004). "Expression of the forkhead transcription factor FOXP1 is associated with estrogen receptor alpha and improved survival in primary human breast carcinomas.". Clin. Cancer Res. 10 (10): 3521–7. doi:10.1158/1078-0432.CCR-03-0461. PMID 15161711.  
  • Shi C, Zhang X, Chen Z, et al. (2004). "Integrin engagement regulates monocyte differentiation through the forkhead transcription factor Foxp1.". J. Clin. Invest. 114 (3): 408–18. doi:10.1172/JCI200421100. PMID 15286807.  
  • Streubel B, Vinatzer U, Lamprecht A, et al. (2005). "T(3;14)(p14.1;q32) involving IGH and FOXP1 is a novel recurrent chromosomal aberration in MALT lymphoma.". Leukemia 19 (4): 652–8. doi:10.1038/sj.leu.2403644. PMID 15703784.  
  • Banham AH, Connors JM, Brown PJ, et al. (2005). "Expression of the FOXP1 transcription factor is strongly associated with inferior survival in patients with diffuse large B-cell lymphoma.". Clin. Cancer Res. 11 (3): 1065–72. PMID 15709173.  
  • Brown P, Marafioti T, Kusec R, Banham AH (2007). "The FOXP1 transcription factor is expressed in the majority of follicular lymphomas but is rarely expressed in classical and lymphocyte predominant Hodgkin's lymphoma.". J. Mol. Histol. 36 (4): 249–56. doi:10.1007/s10735-005-6521-3. PMID 16200457.  
  • Giatromanolaki A, Koukourakis MI, Sivridis E, et al. (2006). "Loss of expression and nuclear/cytoplasmic localization of the FOXP1 forkhead transcription factor are common events in early endometrial cancer: relationship with estrogen receptors and HIF-1alpha expression.". Mod. Pathol. 19 (1): 9–16. doi:10.1038/modpathol.3800494. PMID 16258506.  
  • Sagaert X, de Paepe P, Libbrecht L, et al. (2006). "Forkhead box protein P1 expression in mucosa-associated lymphoid tissue lymphomas predicts poor prognosis and transformation to diffuse large B-cell lymphoma.". J. Clin. Oncol. 24 (16): 2490–7. doi:10.1200/JCO.2006.05.6150. PMID 16636337.  
  • Haralambieva E, Adam P, Ventura R, et al. (2007). "Genetic rearrangement of FOXP1 is predominantly detected in a subset of diffuse large B-cell lymphomas with extranodal presentation.". Leukemia 20 (7): 1300–3. doi:10.1038/sj.leu.2404244. PMID 16673020.  
  • Hannenhalli S, Putt ME, Gilmore JM, et al. (2006). "Transcriptional genomics associates FOX transcription factors with human heart failure.". Circulation 114 (12): 1269–76. doi:10.1161/CIRCULATIONAHA.106.632430. PMID 16952980.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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