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Fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
Identifiers
Symbols FUT1; H; HH; HSC
External IDs OMIM211100 MGI109375 HomoloGene120 GeneCards: FUT1 Gene
RNA expression pattern
PBB GE FUT1 206109 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2523 14343
Ensembl ENSG00000174951 ENSMUSG00000008461
UniProt P19526 P97327
RefSeq (mRNA) NM_000148 NM_008051
RefSeq (protein) NP_000139 NP_032077
Location (UCSC) Chr 19:
53.94 - 53.95 Mb
Chr 7:
45.49 - 45.49 Mb
PubMed search [1] [2]

Galactoside 2-alpha-L-fucosyltransferase 1 is an enzyme that in humans is encoded by the FUT1 gene.[1]

References

Further reading

  • Ball SP, Tongue N, Gibaud A, et al. (1992). "The human chromosome 19 linkage group FUT1 (H), FUT2 (SE), LE, LU, PEPD, C3, APOC2, D19S7 and D19S9.". Ann. Hum. Genet. 55 (Pt 3): 225–33. doi:10.1111/j.1469-1809.1991.tb00417.x. PMID 1763885.  
  • Larsen RD, Ernst LK, Nair RP, Lowe JB (1990). "Molecular cloning, sequence, and expression of a human GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase cDNA that can form the H blood group antigen.". Proc. Natl. Acad. Sci. U.S.A. 87 (17): 6674–8. doi:10.1073/pnas.87.17.6674. PMID 2118655.  
  • Reguigne-Arnould I, Couillin P, Mollicone R, et al. (1995). "Relative positions of two clusters of human alpha-L-fucosyltransferases in 19q (FUT1-FUT2) and 19p (FUT6-FUT3-FUT5) within the microsatellite genetic map of chromosome 19.". Cytogenet. Cell Genet. 71 (2): 158–62. doi:10.1159/000134098. PMID 7656588.  
  • Bruneau N, Lombardo D (1995). "Chaperone function of a Grp 94-related protein for folding and transport of the pancreatic bile salt-dependent lipase.". J. Biol. Chem. 270 (22): 13524–33. doi:10.1074/jbc.270.22.13524. PMID 7768954.  
  • Kelly RJ, Ernst LK, Larsen RD, et al. (1994). "Molecular basis for H blood group deficiency in Bombay (Oh) and para-Bombay individuals.". Proc. Natl. Acad. Sci. U.S.A. 91 (13): 5843–7. doi:10.1073/pnas.91.13.5843. PMID 7912436.  
  • Koda Y, Soejima M, Kimura H (1997). "Structure and expression of H-type GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase gene (FUT1). Two transcription start sites and alternative splicing generate several forms of FUT1 mRNA.". J. Biol. Chem. 272 (11): 7501–5. doi:10.1074/jbc.272.11.7501. PMID 9054453.  
  • Wagner FF, Flegel WA (1997). "Polymorphism of the h allele and the population frequency of sporadic nonfunctional alleles.". Transfusion 37 (3): 284–90. doi:10.1046/j.1537-2995.1997.37397240210.x. PMID 9122901.  
  • Kaneko M, Nishihara S, Shinya N, et al. (1997). "Wide variety of point mutations in the H gene of Bombay and para-Bombay individuals that inactivate H enzyme.". Blood 90 (2): 839–49. PMID 9226185.  
  • Koda Y, Soejima M, Johnson PH, et al. (1997). "Missense mutation of FUT1 and deletion of FUT2 are responsible for Indian Bombay phenotype of ABO blood group system.". Biochem. Biophys. Res. Commun. 238 (1): 21–5. doi:10.1006/bbrc.1997.7232. PMID 9299444.  
  • Koda Y, Soejima M, Kimura H (1998). "Changing transcription start sites in H-type alpha(1,2)fucosyltransferase gene (FUT1) during differentiation of the human erythroid lineage.". Eur. J. Biochem. 256 (2): 379–87. doi:10.1046/j.1432-1327.1998.2560379.x. PMID 9760178.  
  • Roos C, Kolmer M, Mattila P, Renkonen R (2002). "Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism.". J. Biol. Chem. 277 (5): 3168–75. doi:10.1074/jbc.M107927200. PMID 11698403.  
  • Yip SP, Chee KY, Chan PY, et al. (2003). "Molecular genetic analysis of para-Bombay phenotypes in Chinese: a novel non-functional FUT1 allele is identified.". Vox Sang. 83 (3): 258–62. doi:10.1046/j.1423-0410.2002.00184.x. PMID 12366770.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • López-Ferrer A, de Bolós C (2003). "The expression of human FUT1 in HT-29/M3 colon cancer cells instructs the glycosylation of MUC1 and MUC5AC apomucins.". Glycoconj. J. 19 (1): 13–21. doi:10.1023/A:1022576712961. PMID 12652076.  
  • Shi S, Stanley P (2003). "Protein O-fucosyltransferase 1 is an essential component of Notch signaling pathways.". Proc. Natl. Acad. Sci. U.S.A. 100 (9): 5234–9. doi:10.1073/pnas.0831126100. PMID 12697902.  
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.  
  • Guo ZH, Xiang D, Zhu ZY, et al.. "[Analysis on FUT1 and FUT2 gene of 10 para-Bombay individuals in China]". Zhonghua Yi Xue Yi Chuan Xue Za Zhi 21 (5): 417–21. PMID 15476160.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Yan L, Zhu F, Xu X, et al. (2005). "Molecular basis for para-Bombay phenotypes in Chinese persons, including a novel nonfunctional FUT1 allele.". Transfusion 45 (5): 725–30. doi:10.1111/j.1537-2995.2005.04305.x. PMID 15847661.  
  • Mejías-Luque R, López-Ferrer A, Garrido M, et al. (2007). "Changes in the invasive and metastatic capacities of HT-29/M3 cells induced by the expression of fucosyltransferase 1.". Cancer Sci. 98 (7): 1000–5. doi:10.1111/j.1349-7006.2007.00484.x. PMID 17459061.  
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