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Frizzled homolog 10 (Drosophila)
Symbols FZD10; FZ-10; FzE7; hFz10
External IDs OMIM606147 MGI2136761 HomoloGene21411 IUPHAR: FZD10 GeneCards: FZD10 Gene
RNA expression pattern
PBB GE FZD10 219764 at tn.png
More reference expression data
Species Human Mouse
Entrez 11211 93897
Ensembl ENSG00000111432 n/a
UniProt Q9ULW2 n/a
RefSeq (mRNA) NM_007197 XM_974070
RefSeq (protein) NP_009128 XP_979164
Location (UCSC) Chr 12:
129.21 - 129.22 Mb
PubMed search [1] [2]

Frizzled-10 is a protein that in humans is encoded by the FZD10 gene.[1][2] FZD10 has also been designated as CD350 (cluster of differentiation 350).

This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer.[2]


See also


  1. ^ Koike J, Takagi A, Miwa T, Hirai M, Terada M, Katoh M (Sep 1999). "Molecular cloning of Frizzled-10, a novel member of the Frizzled gene family". Biochem Biophys Res Commun 262 (1): 39-43. doi:10.1006/bbrc.1999.1161. PMID 10448064.  
  2. ^ a b "Entrez Gene: FZD10 frizzled homolog 10 (Drosophila)".  

Further reading

  • Finch PW, He X, Kelley MJ, et al. (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. doi:10.1073/pnas.94.13.6770. PMID 9192640.  
  • Tanaka S, Akiyoshi T, Mori M, et al. (1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10164–9. doi:10.1073/pnas.95.17.10164. PMID 9707618.  
  • Kumar S, Connor JR, Dodds RA, et al. (2001). "Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries.". Osteoarthr. Cartil. 9 (7): 641–53. doi:10.1053/joca.2001.0421. PMID 11597177.  
  • Terasaki H, Saitoh T, Shiokawa K, Katoh M (2002). "Frizzled-10, up-regulated in primary colorectal cancer, is a positive regulator of the WNT - beta-catenin - TCF signaling pathway.". Int. J. Mol. Med. 9 (2): 107–12. PMID 11786918.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Omoto S, Hayashi T, Kitahara K, et al. (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R).". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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