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Frizzled homolog 2 (Drosophila)
Identifiers
Symbols FZD2;
External IDs OMIM600667 MGI1888513 HomoloGene20377 IUPHAR: FZD2 GeneCards: FZD2 Gene
RNA expression pattern
PBB GE FZD2 210220 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2535 57265
Ensembl ENSG00000180340 ENSMUSG00000050288
UniProt Q14332 Q923Z9
RefSeq (mRNA) NM_001466 NM_020510
RefSeq (protein) NP_001457 NP_065256
Location (UCSC) Chr 17:
39.99 - 39.99 Mb
Chr 11:
102.42 - 102.42 Mb
PubMed search [1] [2]

Frizzled-2 is a protein that in humans is encoded by the FZD2 gene.[1][2][3]

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The expression of the FZD2 gene appears to be developmentally regulated, with high levels of expression in fetal kidney and lung and in adult colon and ovary.[3]

Contents

See also

References

  1. ^ Zhao Z, Lee CC, Baldini A, Caskey CT (Nov 1995). "A human homologue of the Drosophila polarity gene frizzled has been identified and mapped to 17q21.1". Genomics 27 (2): 370-3. doi:10.1006/geno.1995.1060. PMID 7558010.  
  2. ^ Sagara N, Toda G, Hirai M, Terada M, Katoh M (Dec 1998). "Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7". Biochem Biophys Res Commun 252 (1): 117-22. doi:10.1006/bbrc.1998.9607. PMID 9813155.  
  3. ^ a b "Entrez Gene: FZD2 frizzled homolog 2 (Drosophila)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2535.  

External links

Further reading

  • Wang Y, Macke JP, Abella BS, et al. (1996). "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled.". J. Biol. Chem. 271 (8): 4468–76. doi:10.1074/jbc.271.8.4468. PMID 8626800.  
  • Finch PW, He X, Kelley MJ, et al. (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. doi:10.1073/pnas.94.13.6770. PMID 9192640.  
  • Tanaka S, Akiyoshi T, Mori M, et al. (1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10164–9. doi:10.1073/pnas.95.17.10164. PMID 9707618.  
  • Hering H, Sheng M (2002). "Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95.". FEBS Lett. 521 (1-3): 185–9. doi:10.1016/S0014-5793(02)02831-4. PMID 12067714.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Oishi I, Suzuki H, Onishi N, et al. (2004). "The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway.". Genes Cells 8 (7): 645–54. doi:10.1046/j.1365-2443.2003.00662.x. PMID 12839624.  
  • Omoto S, Hayashi T, Kitahara K, et al. (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R).". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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