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Frizzled homolog 3 (Drosophila)
Symbols FZD3; Fz-3; hFz3
External IDs OMIM606143 MGI108476 HomoloGene23004 IUPHAR: FZD3 GeneCards: FZD3 Gene
RNA expression pattern
PBB GE FZD3 219683 at tn.png
More reference expression data
Species Human Mouse
Entrez 7976 14365
Ensembl ENSG00000104290 ENSMUSG00000007989
UniProt Q9NPG1 Q3TUV1
RefSeq (mRNA) NM_017412 NM_021458
RefSeq (protein) NP_059108 NP_067433
Location (UCSC) Chr 8:
28.41 - 28.49 Mb
Chr 14:
64.16 - 64.22 Mb
PubMed search [1] [2]

Frizzled-3 is a protein that in humans is encoded by the FZD3 gene.[1][2][3]

This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. The function of this protein is unknown, although it may play a role in mammalian hair follicle development.[3]


See also


  1. ^ Kirikoshi H, Koike J, Sagara N, Saitoh T, Tokuhara M, Tanaka K, Sekihara H, Hirai M, Katoh M (Jun 2000). "Molecular cloning and genomic structure of human frizzled-3 at chromosome 8p21". Biochem Biophys Res Commun 271 (1): 8-14. doi:10.1006/bbrc.2000.2578. PMID 10777673.  
  2. ^ Sala CF, Formenti E, Terstappen GC, Caricasole A (Jul 2000). "Identification, gene structure, and expression of human frizzled-3 (FZD3)". Biochem Biophys Res Commun 273 (1): 27-34. doi:10.1006/bbrc.2000.2882. PMID 10873558.  
  3. ^ a b "Entrez Gene: FZD3 frizzled homolog 3 (Drosophila)".  

External links

Further reading

  • Katoh M (2002). "GIPC gene family (Review).". Int. J. Mol. Med. 9 (6): 585–9. PMID 12011974.  
  • Finch PW, He X, Kelley MJ, et al. (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. doi:10.1073/pnas.94.13.6770. PMID 9192640.  
  • Wright M, Aikawa M, Szeto W, Papkoff J (1999). "Identification of a Wnt-responsive signal transduction pathway in primary endothelial cells.". Biochem. Biophys. Res. Commun. 263 (2): 384–8. doi:10.1006/bbrc.1999.1344. PMID 10491302.  
  • Hung BS, Wang XQ, Cam GR, Rothnagel JA (2001). "Characterization of mouse Frizzled-3 expression in hair follicle development and identification of the human homolog in keratinocytes.". J. Invest. Dermatol. 116 (6): 940–6. doi:10.1046/j.1523-1747.2001.01336.x. PMID 11407985.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Katsu T, Ujike H, Nakano T, et al. (2004). "The human frizzled-3 (FZD3) gene on chromosome 8p21, a receptor gene for Wnt ligands, is associated with the susceptibility to schizophrenia.". Neurosci. Lett. 353 (1): 53–6. doi:10.1016/j.neulet.2003.09.017. PMID 14642436.  
  • Zhang Y, Yu X, Yuan Y, et al. (2005). "Positive association of the human frizzled 3 (FZD3) gene haplotype with schizophrenia in Chinese Han population.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 129 (1): 16–9. doi:10.1002/ajmg.b.30076. PMID 15274031.  
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMID 15340161.  
  • Omoto S, Hayashi T, Kitahara K, et al. (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R).". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539.  
  • Hashimoto R, Suzuki T, Iwata N, et al. (2005). "Association study of the frizzled-3 (FZD3) gene with schizophrenia and mood disorders.". Journal of neural transmission (Vienna, Austria : 1996) 112 (2): 303–7. doi:10.1007/s00702-004-0264-2. PMID 15657645.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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