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Frizzled homolog 3 (Drosophila)
Identifiers
Symbols FZD3; Fz-3; hFz3
External IDs OMIM606143 MGI108476 HomoloGene23004 IUPHAR: FZD3 GeneCards: FZD3 Gene
RNA expression pattern
PBB GE FZD3 219683 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7976 14365
Ensembl ENSG00000104290 ENSMUSG00000007989
UniProt Q9NPG1 Q3TUV1
RefSeq (mRNA) NM_017412 NM_021458
RefSeq (protein) NP_059108 NP_067433
Location (UCSC) Chr 8:
28.41 - 28.49 Mb
Chr 14:
64.16 - 64.22 Mb
PubMed search [1] [2]

Frizzled-3 is a protein that in humans is encoded by the FZD3 gene.[1][2][3]

This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. The function of this protein is unknown, although it may play a role in mammalian hair follicle development.[3]

Contents

See also

References

  1. ^ Kirikoshi H, Koike J, Sagara N, Saitoh T, Tokuhara M, Tanaka K, Sekihara H, Hirai M, Katoh M (Jun 2000). "Molecular cloning and genomic structure of human frizzled-3 at chromosome 8p21". Biochem Biophys Res Commun 271 (1): 8-14. doi:10.1006/bbrc.2000.2578. PMID 10777673.  
  2. ^ Sala CF, Formenti E, Terstappen GC, Caricasole A (Jul 2000). "Identification, gene structure, and expression of human frizzled-3 (FZD3)". Biochem Biophys Res Commun 273 (1): 27-34. doi:10.1006/bbrc.2000.2882. PMID 10873558.  
  3. ^ a b "Entrez Gene: FZD3 frizzled homolog 3 (Drosophila)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7976.  

External links

Further reading

  • Katoh M (2002). "GIPC gene family (Review).". Int. J. Mol. Med. 9 (6): 585–9. PMID 12011974.  
  • Finch PW, He X, Kelley MJ, et al. (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. doi:10.1073/pnas.94.13.6770. PMID 9192640.  
  • Wright M, Aikawa M, Szeto W, Papkoff J (1999). "Identification of a Wnt-responsive signal transduction pathway in primary endothelial cells.". Biochem. Biophys. Res. Commun. 263 (2): 384–8. doi:10.1006/bbrc.1999.1344. PMID 10491302.  
  • Hung BS, Wang XQ, Cam GR, Rothnagel JA (2001). "Characterization of mouse Frizzled-3 expression in hair follicle development and identification of the human homolog in keratinocytes.". J. Invest. Dermatol. 116 (6): 940–6. doi:10.1046/j.1523-1747.2001.01336.x. PMID 11407985.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Katsu T, Ujike H, Nakano T, et al. (2004). "The human frizzled-3 (FZD3) gene on chromosome 8p21, a receptor gene for Wnt ligands, is associated with the susceptibility to schizophrenia.". Neurosci. Lett. 353 (1): 53–6. doi:10.1016/j.neulet.2003.09.017. PMID 14642436.  
  • Zhang Y, Yu X, Yuan Y, et al. (2005). "Positive association of the human frizzled 3 (FZD3) gene haplotype with schizophrenia in Chinese Han population.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 129 (1): 16–9. doi:10.1002/ajmg.b.30076. PMID 15274031.  
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMID 15340161.  
  • Omoto S, Hayashi T, Kitahara K, et al. (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R).". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539.  
  • Hashimoto R, Suzuki T, Iwata N, et al. (2005). "Association study of the frizzled-3 (FZD3) gene with schizophrenia and mood disorders.". Journal of neural transmission (Vienna, Austria : 1996) 112 (2): 303–7. doi:10.1007/s00702-004-0264-2. PMID 15657645.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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