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Frizzled homolog 5 (Drosophila)
Symbols FZD5; C2orf31; DKFZP434E2135; HFZ5; MGC129692
External IDs OMIM601723 MGI108571 HomoloGene2590 IUPHAR: FZD5 GeneCards: FZD5 Gene
RNA expression pattern
PBB GE FZD5 206136 at tn.png
More reference expression data
Species Human Mouse
Entrez 7855 14367
Ensembl ENSG00000163251 ENSMUSG00000045005
UniProt Q13467 Q149L3
RefSeq (mRNA) NM_003468 NM_001033193
RefSeq (protein) NP_003459 NP_001028365
Location (UCSC) Chr 2:
208.34 - 208.34 Mb
Chr 1:
64.67 - 64.67 Mb
PubMed search [1] [2]

Frizzled-5 is a protein that in humans is encoded by the FZD5 gene.[1][2][3]

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD5 protein is believed to be the receptor for the Wnt5A ligand.[3]


See also


  1. ^ Wang Y, Macke JP, Abella BS, Andreasson K, Worley P, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J (Jun 1996). "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled". J Biol Chem 271 (8): 4468-76. PMID 8626800.  
  2. ^ Saitoh T, Hirai M, Katoh M (Jun 2001). "Molecular cloning and characterization of human Frizzled-5 gene on chromosome 2q33.3-q34 region". Int J Oncol 19 (1): 105-10. PMID 11408929.  
  3. ^ a b "Entrez Gene: FZD5 frizzled homolog 5 (Drosophila)".  

External links

Further reading

  • He X, Saint-Jeannet JP, Wang Y, et al. (1997). "A member of the Frizzled protein family mediating axis induction by Wnt-5A.". Science 275 (5306): 1652–4. doi:10.1126/science.275.5306.1652. PMID 9054360.  
  • Finch PW, He X, Kelley MJ, et al. (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. doi:10.1073/pnas.94.13.6770. PMID 9192640.  
  • Tanaka S, Akiyoshi T, Mori M, et al. (1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10164–9. doi:10.1073/pnas.95.17.10164. PMID 9707618.  
  • Tamai K, Semenov M, Kato Y, et al. (2000). "LDL-receptor-related proteins in Wnt signal transduction.". Nature 407 (6803): 530–5. doi:10.1038/35035117. PMID 11029007.  
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.  
  • Yao R, Maeda T, Takada S, Noda T (2001). "Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled.". Biochem. Biophys. Res. Commun. 286 (4): 771–8. doi:10.1006/bbrc.2001.5430. PMID 11520064.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Weidler C, Schaumburger J, Miller LE, et al. (2004). "Synovial density of frizzled 5-positive cells does not differ between patients with RA and OA and is independent of inflammation.". J. Rheumatol. 31 (9): 1874–5. PMID 15338479.  
  • Omoto S, Hayashi T, Kitahara K, et al. (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R).". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539.  
  • Holmen SL, Robertson SA, Zylstra CR, Williams BO (2005). "Wnt-independent activation of beta-catenin mediated by a Dkk1-Fz5 fusion protein.". Biochem. Biophys. Res. Commun. 328 (2): 533–9. doi:10.1016/j.bbrc.2005.01.009. PMID 15694380.  
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.  
  • Blumenthal A, Ehlers S, Lauber J, et al. (2006). "The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation.". Blood 108 (3): 965–73. doi:10.1182/blood-2005-12-5046. PMID 16601243.  
  • Yamamoto H, Komekado H, Kikuchi A (2006). "Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin.". Dev. Cell 11 (2): 213–23. doi:10.1016/j.devcel.2006.07.003. PMID 16890161.  
  • Katoh Y, Katoh M (2007). "Conserved POU-binding site linked to SP1-binding site within FZD5 promoter: Transcriptional mechanisms of FZD5 in undifferentiated human ES cells, fetal liver/spleen, adult colon, pancreatic islet, and diffuse-type gastric cancer.". Int. J. Oncol. 30 (3): 751–5. PMID 17273778.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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