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Frizzled homolog 6 (Drosophila)
Symbols FZD6; Hfz6
External IDs OMIM603409 MGI108474 HomoloGene2617 IUPHAR: FZD6 GeneCards: FZD6 Gene
RNA expression pattern
PBB GE FZD6 203987 at tn.png
More reference expression data
Species Human Mouse
Entrez 8323 14368
Ensembl ENSG00000164930 ENSMUSG00000022297
UniProt O60353 Q3UTZ0
RefSeq (mRNA) NM_003506 NM_008056
RefSeq (protein) NP_003497 NP_032082
Location (UCSC) Chr 8:
104.38 - 104.41 Mb
Chr 15:
38.84 - 38.87 Mb
PubMed search [1] [2]

Frizzled-6 is a protein that in humans is encoded by the FZD6 gene.[1][2][3]

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD6 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and 7 transmembrane domains. However, unlike many other Fz family members, FDZ6 does not contain a C-terminal PDZ domain-binding motif.[3]



FZD6 has been shown to interact with Secreted frizzled-related protein 1.[4]

See also


  1. ^ Tokuhara M, Hirai M, Atomi Y, Terada M, Katoh M (Mar 1998). "Molecular cloning of human Frizzled-6". Biochem Biophys Res Commun 243 (2): 622–7. doi:10.1006/bbrc.1998.8143. PMID 9480858.  
  2. ^ Golan T, Yaniv A, Bafico A, Liu G, Gazit A (Apr 2004). "The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascade". J Biol Chem 279 (15): 14879–88. doi:10.1074/jbc.M306421200. PMID 14747478.  
  3. ^ a b "Entrez Gene: FZD6 frizzled homolog 6 (Drosophila)".  
  4. ^ Bafico, A; Gazit A, Pramila T, Finch P W, Yaniv A, Aaronson S A (Jun. 1999). "Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling". J. Biol. Chem. (UNITED STATES) 274 (23): 16180–7. ISSN 0021-9258. PMID 10347172.  

External links

Further reading

  • Wang Y, Macke JP, Abella BS, et al. (1996). "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled.". J. Biol. Chem. 271 (8): 4468–76. doi:10.1074/jbc.271.8.4468. PMID 8626800.  
  • Finch PW, He X, Kelley MJ, et al. (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. doi:10.1073/pnas.94.13.6770. PMID 9192640.  
  • Bafico A, Gazit A, Pramila T, et al. (1999). "Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling.". J. Biol. Chem. 274 (23): 16180–7. doi:10.1074/jbc.274.23.16180. PMID 10347172.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Omoto S, Hayashi T, Kitahara K, et al. (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R).". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.  
  • Sirchia R, Luparello C (2007). "Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells.". Biol. Chem. 388 (5): 457–65. doi:10.1515/BC.2007.059. PMID 17516841.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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