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FZD7: Wikis


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Frizzled homolog 7 (Drosophila)
Symbols FZD7; FzE3
External IDs OMIM603410 MGI108570 HomoloGene20751 IUPHAR: FZD7 GeneCards: FZD7 Gene
RNA expression pattern
PBB GE FZD7 203706 s at tn.png
PBB GE FZD7 203705 s at tn.png
More reference expression data
Species Human Mouse
Entrez 8324 14369
Ensembl ENSG00000155760 ENSMUSG00000041075
UniProt O75084 Q6P551
RefSeq (mRNA) NM_003507 NM_008057
RefSeq (protein) NP_003498 NP_032083
Location (UCSC) Chr 2:
202.61 - 202.61 Mb
Chr 1:
59.43 - 59.43 Mb
PubMed search [1] [2]

Frizzled-7 is a protein that in humans is encoded by the FZD7 gene.[1][2][3]

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.[3]



FZD7 has been shown to interact with DLG4.[4]

See also


  1. ^ Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K (Sep 1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals". Proc Natl Acad Sci U S A 95 (17): 10164–9. PMID 9707618.  
  2. ^ Sagara N, Toda G, Hirai M, Terada M, Katoh M (Dec 1998). "Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7". Biochem Biophys Res Commun 252 (1): 117–22. doi:10.1006/bbrc.1998.9607. PMID 9813155.  
  3. ^ a b "Entrez Gene: FZD7 frizzled homolog 7 (Drosophila)".  
  4. ^ Hering, Heike; Sheng Morgan (Jun. 2002). "Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95". FEBS Lett. (Netherlands) 521 (1-3): 185–9. ISSN 0014-5793. PMID 12067714.  

External links

Further reading

  • Finch PW, He X, Kelley MJ, et al. (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. doi:10.1073/pnas.94.13.6770. PMID 9192640.  
  • Hering H, Sheng M (2002). "Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95.". FEBS Lett. 521 (1-3): 185–9. doi:10.1016/S0014-5793(02)02831-4. PMID 12067714.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Yao R, Natsume Y, Noda T (2005). "MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap.". Oncogene 23 (36): 6023–30. doi:10.1038/sj.onc.1207817. PMID 15195140.  
  • Omoto S, Hayashi T, Kitahara K, et al. (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R).". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Vincan E, Darcy PK, Smyth MJ, et al. (2005). "Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and attenuates tumor growth.". Differentiation 73 (4): 142–53. doi:10.1111/j.1432-0436.2005.00015.x. PMID 15901282.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.  
  • Vincan E, Darcy PK, Farrelly CA, et al. (2007). "Frizzled-7 dictates three-dimensional organization of colorectal cancer cell carcinoids.". Oncogene 26 (16): 2340–52. doi:10.1038/sj.onc.1210026. PMID 17016432.  
  • Struewing IT, Barnett CD, Zhang W, et al. (2007). "Frizzled-7 turnover at the plasma membrane is regulated by cell density and the Ca(2+) -dependent protease calpain-1.". Exp. Cell Res. 313 (16): 3526–41. doi:10.1016/j.yexcr.2007.07.012. PMID 17716656.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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