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Frizzled homolog 8 (Drosophila)

PDB rendering based on 1ijy.
Available structures
Symbols FZD8; FZ-8; hFZ8
External IDs OMIM606146 MGI108460 HomoloGene40606 IUPHAR: FZD8 GeneCards: FZD8 Gene
RNA expression pattern
PBB GE FZD8 216587 s at tn.png
More reference expression data
Species Human Mouse
Entrez 8325 14370
Ensembl ENSG00000177283 ENSMUSG00000036904
UniProt Q9H461 Q61091
RefSeq (mRNA) NM_031866 NM_008058
RefSeq (protein) NP_114072 NP_032084
Location (UCSC) Chr 10:
35.97 - 35.97 Mb
Chr 18:
9.21 - 9.21 Mb
PubMed search [1] [2]

Frizzled-8 is a protein that in humans is encoded by the FZD8 gene.[1][2]

This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.[2]


See also


  1. ^ Saitoh T, Hirai M, Katoh M (Apr 2001). "Molecular cloning and characterization of human Frizzled-8 gene on chromosome 10p11.2". Int J Oncol 18 (5): 991-6. PMID 11295046.  
  2. ^ a b "Entrez Gene: FZD8 frizzled homolog 8 (Drosophila)".  

External links

Further reading

  • Wang Y, Macke JP, Abella BS, et al. (1996). "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled.". J. Biol. Chem. 271 (8): 4468–76. PMID 8626800.  
  • Finch PW, He X, Kelley MJ, et al. (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. PMID 9192640.  
  • Tamai K, Semenov M, Kato Y, et al. (2000). "LDL-receptor-related proteins in Wnt signal transduction.". Nature 407 (6803): 530–5. doi:10.1038/35035117. PMID 11029007.  
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.  
  • Semënov MV, Tamai K, Brott BK, et al. (2001). "Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6.". Curr. Biol. 11 (12): 951–61. PMID 11448771.  
  • Dann CE, Hsieh JC, Rattner A, et al. (2001). "Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains.". Nature 412 (6842): 86–90. doi:10.1038/35083601. PMID 11452312.  
  • Yao R, Maeda T, Takada S, Noda T (2001). "Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled.". Biochem. Biophys. Res. Commun. 286 (4): 771–8. doi:10.1006/bbrc.2001.5430. PMID 11520064.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.  
  • Omoto S, Hayashi T, Kitahara K, et al. (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R).". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539.  
  • Lu W, Yamamoto V, Ortega B, Baltimore D (2004). "Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth.". Cell 119 (1): 97–108. doi:10.1016/j.cell.2004.09.019. PMID 15454084.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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