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Frizzled homolog 9 (Drosophila)
Symbols FZD9; FZD3
External IDs OMIM601766 MGI1313278 HomoloGene2619 IUPHAR: FZD9 GeneCards: FZD9 Gene
RNA expression pattern
PBB GE FZD9 207639 at tn.png
More reference expression data
Species Human Mouse
Entrez 8326 14371
Ensembl ENSG00000188763 ENSMUSG00000049551
UniProt O00144 Q9R216
RefSeq (mRNA) NM_003508 XM_284144
RefSeq (protein) NP_003499 XP_284144
Location (UCSC) Chr 7:
72.49 - 72.49 Mb
Chr 5:
135.53 - 135.54 Mb
PubMed search [1] [2]

Frizzled-9 is a protein that in humans is encoded by the FZD9 gene.[1][2][3] FZD9 has also been designated as CD349 (cluster of differentiation 349).

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7, and heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype. FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney.[3]


See also


  1. ^ Wang YK, Samos CH, Peoples R, Perez-Jurado LA, Nusse R, Francke U (May 1997). "A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11.23". Hum Mol Genet 6 (3): 465-72. PMID 9147651.  
  2. ^ Wang YK, Sporle R, Paperna T, Schughart K, Francke U (May 1999). "Characterization and expression pattern of the frizzled gene Fzd9, the mouse homolog of FZD9 which is deleted in Williams-Beuren syndrome". Genomics 57 (2): 235-48. doi:10.1006/geno.1999.5773. PMID 10198163.  
  3. ^ a b "Entrez Gene: FZD9 frizzled homolog 9 (Drosophila)".  

Further reading

  • Datta DV (1977). "Viral hepatitis (Chandigarh study).". The Journal of the Association of Physicians of India 25 (5): 325–30. PMID 914765.  
  • Finch PW, He X, Kelley MJ, et al. (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. doi:10.1073/pnas.94.13.6770. PMID 9192640.  
  • Tanaka S, Akiyoshi T, Mori M, et al. (1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10164–9. doi:10.1073/pnas.95.17.10164. PMID 9707618.  
  • Karasawa T, Yokokura H, Kitajewski J, Lombroso PJ (2002). "Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta -catenin signaling.". J. Biol. Chem. 277 (40): 37479–86. doi:10.1074/jbc.M205658200. PMID 12138115.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.  
  • Omoto S, Hayashi T, Kitahara K, et al. (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R).". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539.  
  • Winn RA, Marek L, Han SY, et al. (2005). "Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation.". J. Biol. Chem. 280 (20): 19625–34. doi:10.1074/jbc.M409392200. PMID 15705594.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
  • Winn RA, Van Scoyk M, Hammond M, et al. (2006). "Antitumorigenic effect of Wnt 7a and Fzd 9 in non-small cell lung cancer cells is mediated through ERK-5-dependent activation of peroxisome proliferator-activated receptor gamma.". J. Biol. Chem. 281 (37): 26943–50. doi:10.1074/jbc.M604145200. PMID 16835228.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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