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Systematic (IUPAC) name
CAS number 2240-14-4
ATC code N06BA06
PubChem 14584
Chemical data
Formula C 15H21N 
Mol. mass  ?
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status Schedule IV (USA)
Routes  ?

Fencamfamine (Glucoenergan, Reactivan) is a stimulant which was developed in the 1960s as an appetite suppressant, but was later withdrawn for this application due to problems with dependence and abuse. It is around half the potency of dextroamphetamine, and is prescribed at a dose of 10-60mg, although abusers of the drug tend to rapidly develop tolerance and escalate their dose. Reactivan is still rarely used for treating depressive day-time fatigue, lack of concentration and lethargy, particularly in individuals who have chronic medical conditions, as its favourable safety profile makes it the most suitable drug in some cases.[1]

Fencamfamine acts as an indirect dopamine agonist. It releases dopamine by a similar mechanism to amphetamines, but is ten times less potent than dexamphetamine at producing this effect. The main mechanism of action is instead inhibition of dopamine reuptake, more similar to that of methylphenidate. Also unlike amphetamines, fencamfamine does not inhibit the action of monoamine oxidase enzymes and so is somewhat safer.[2] Some experiments also suggest a role for opioid receptors in the activity of fencamfamine, as low doses can cause paradoxical sedation, and some effects of the drug are blocked by naloxone.[3]

See also


  1. ^ REACTIVAN Tablets; REACTIVAN Syrup
  2. ^ Seyfried, CA (1983). "Dopamine uptake inhibiting versus dopamine releasing properties of fencamfamine: an in vitro study". Biochemical pharmacology 32 (15): 2329–31. doi:10.1016/0006-2952(83)90181-8. PMID 6136281.   edit
  3. ^ Planeta Cda, S; Aizenstein; Delucia (1995). "Reinforcing properties of fencamfamine: involvement of dopamine and opioid receptors". Pharmacology, biochemistry, and behavior 50 (1): 35–40. doi:10.1016/0091-3057(94)00236-C. PMID 7700952.   edit

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