The Full Wiki

Fenoprofen: Wikis


Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.


From Wikipedia, the free encyclopedia

Systematic (IUPAC) name
2-(3-phenoxyphenyl)propanoic acid
CAS number 29679-58-1
ATC code M01AE04
PubChem 3342
Chemical data
Formula C 15H14O3  
Mol. mass 242.26986 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism Major urinary metabolites are fenoprofen glucuronide and 4′-hydroxyfenoprofen glucuronide.
Half life 3 hours
Excretion Renal (~90%)
Therapeutic considerations
Pregnancy cat. C
Legal status POM (UK)
Routes Oral

Fenoprofen is a non-steroidal anti-inflammatory drug. Fenoprofen calcium is used for symptomatic relief for rheumatoid arthritis, osteoarthritis, and mild to moderate pain.



Decreases inflammation, pain, and fever, probably through inhibition of cyclooxygenase activity and prostaglandin synthesis.


History of significantly impaired renal function; patients with known hypersensitivity to any component of the product; patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs; treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery.

Drug Interactions

Aminoglycosides (eg, gentamicin): Plasma aminoglycoside levels may be elevated.
Angiotensin-converting enzyme (ACE) inhibitors: Antihypertensive effect of ACE inhibitors may be diminished.
Anticoagulants: Coadministration may prolong prothrombin time.
Aspirin: Fenoprofen Cl may be increased; coadministration is not recommended.
Diuretics: Patients treated with fenoprofen may be resistant to the effects of loop diuretics and thiazides.
Hydantoins, sulfonamides, sulfonylureas: Fenoprofen may displace these drugs from their binding site.
Lithium: Renal Cl of lithium may be reduced and plasma levels may be elevated, which may increase the risk of lithium toxicity.
Methotrexate: May increase methotrexate levels.
Phenobarbital: May decrease fenoprofen t ½ . Dosage adjustments of fenoprofen may be required if phenobarbital is added or withdrawn.
SSRIs (eg, fluoxetine, citalopram): The risk of GI effects may be increased.

Laboratory Test Interactions

False elevation in free and total serum T 3 as measured by Amerlex-M kit.

Brand names

  • UK - Fenopron (Typharm Limited)


Fenoprofen info from

Got something to say? Make a comment.
Your name
Your email address