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Fenticonazole
Systematic (IUPAC) name
1-[2-(2,4-dichlorophenyl)-2-{[4-(phenylsulfanyl)phenyl]methoxy}ethyl]-1 H-imidazole
Identifiers
CAS number 72479-26-6
ATC code D01AC12 G01AF12
PubChem 51755
Chemical data
Formula C 24H20Cl2N2OS 
Mol. mass 455.4 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status prescription
Routes ovule, spray, cream

Fenticonazole is an azole antifungal drug.

Adverse Effects and Precautions Burning and itching have been reported after the application of fenticonazole nitrate.

Intravaginal preparations of fenticonazole may damage latex contraceptives and additional contraceptive measures are therefore necessary during local administration.

For a discussion of the caution needed when using azole antifungals during pregnancy, see under Pregnancy in Precautions of Fluconazole, .

Antimicrobial Action Fenticonazole is an imidazole antifungal active against a range of organisms including dermatophyte pathogens, Malassezia furfur, and Candida albicans.

Uses and Administration Fenticonazole is an imidazole antifungal used locally as the nitrate in the treatment of vulvovaginal candidiasis (). A 200-mg pessary is inserted into the vagina at bedtime for 3 nights or a 600-mg pessary is inserted once only at bedtime. Fenticonazole nitrate is also applied topically as a 2% cream or solution for the treatment of fungal skin infections.

Preparations Single-ingredient Preparations The symbol ¤ denotes a preparation which is discontinued or no longer actively marketed.

Argentina: Lomexin¤; Austria: Fenizolan¤; Lomexin; Brazil: Fentizol; Lomexin; Czech Republic: Lomexin; France: Lomexin; Terlomexin; Germany: Fenizolan; Lomexin; Greece: Lomexin; Hungary: Gynoxin; Italy: Falvin; Fentiderm¤; Fentigyn¤; Lomexin; Mexico: Lomexin; South Africa: Lomexin; Singapore: Lomexin¤; Spain: Laurimic; Lomexin; Micofulvin¤; Switzerland: Mycodermil; United Kingdom: Lomexin¤; Venezuela: Mycofentin;

References

  • The Merck Index, 12th Edition. 4047
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