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Flesinoxan
Systematic (IUPAC) name
4-fluoro-N-[2-[4-[(3S)-3-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-8-yl]piperazin-1-yl]ethyl]benzamide
Identifiers
CAS number 98206-10-1
ATC code none
PubChem 57347
Chemical data
Formula C 22H26FN3O4  
Mol. mass 415.458 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Flesinoxan (DU-29,373) is a psychoactive drug and research chemical of the piperazine chemical class that is being investigated for its antidepressant and anxiolytic effects.[1] It acts as a high affinity and selective 5-HT1A receptor partial or full agonist.[2][3][4] Clinical studies have found flesinoxan to be highly effective against treatment-resistant major depression with few to no side effects.[5][6] In patients it enhances REM sleep latency, decreases body temperature, and increases adrenocorticotropic hormone (ACTH), cortisol, prolactin, and growth hormone secretion.[7][8]

References

  1. ^ Cryan JF, Redmond AM, Kelly JP, Leonard BE. (1997). "The effects of the 5-HT1A agonist flesinoxan, in three paradigms for assessing antidepressant potential in the rat.". Eur Neuropsychopharmacol. 7 (2): 109–114. doi:10.1016/S0924-977X(96)00391-4. PMID 9169298.  
  2. ^ Schoeffter P, Hoyer D. (1988). "Centrally acting hypotensive agents with affinity for 5-HT1A binding sites inhibit forskolin-stimulated adenylate cyclase activity in calf hippocampus.". Br J Pharmacol. 95 (3): 975–985. PMID 3207999.  
  3. ^ Pitchot W, Wauthy J, Legros JJ, Ansseau M. Hormonal and temperature responses to flesinoxan in normal volunteers: an antagonist study. European Neuropsychopharmacology. 2004 Mar;14(2):151-5. PMID 15013031
  4. ^ Hadrava V, Blier P, Dennis T, Ortemann C, de Montigny C (October 1995). "Characterization of 5-hydroxytryptamine1A properties of flesinoxan: in vivo electrophysiology and hypothermia study". Neuropharmacology 34 (10): 1311–26. doi:10.1016/0028-3908(95)00098-Q. PMID 8570029. http://linkinghub.elsevier.com/retrieve/pii/002839089500098Q.  
  5. ^ Grof P, Joffe R, Kennedy S, Persad E, Syrotiuk J, Bradford D. (1993). "An open study of oral flesinoxan, a 5-HT1A receptor agonist, in treatment-resistant depression.". Int Clin Psychopharmacol. 8 (3): 167–172. PMID 8263314.  
  6. ^ Marc Ansseau, William Pitchot, Antonio Gonzalez Moreno, Jacques Wauthy, Patrick Papart (2004). "Pilot study of flesinoxan, a 5-HT1A agonist, in major depression: Effects on sleep REM latency and body temperature.". Human Psychopharmacology: Clinical and Experimental 8 (4): 279–283. doi:10.1002/hup.470080407. http://www3.interscience.wiley.com/journal/109710934/abstract.  
  7. ^ Marc Ansseau, William Pitchot, Antonio Gonzalez Moreno, Jacques Wauthy, Patrick Papart (2004). "Pilot study of flesinoxan, a 5-HT1A agonist, in major depression: Effects on sleep REM latency and body temperature.". Human Psychopharmacology: Clinical and Experimental 8 (4): 279–283. doi:10.1002/hup.470080407. http://www3.interscience.wiley.com/journal/109710934/abstract.  
  8. ^ Pitchot W, Wauthy J, Legros JJ, Ansseau M (March 2004). "Hormonal and temperature responses to flesinoxan in normal volunteers: an antagonist study". European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology 14 (2): 151–5. doi:10.1016/S0924-977X(03)00108-1. PMID 15013031.  







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