The Full Wiki

More info on Fludiazepam

Fludiazepam: Wikis


Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

Fludiazepam
Systematic (IUPAC) name
9-chloro-6-(2-fluorophenyl)- 2-methyl-2,5-diazabicyclo [5.4.0]undeca- 5,8,10,12-tetraen-3-one
Identifiers
CAS number 3900-31-0
ATC code N05BA17
PubChem 3369
DrugBank ?
Chemical data
Formula C 16H12ClFN2O 
Mol. mass 302.7
Pharmacokinetic data
Bioavailability  ?
Metabolism Hepatic
Half life  ?
Excretion Renal
Therapeutic considerations
Pregnancy cat.  ?
Legal status Schedule IV(US)
Routes Oral
 Yes check.svgY(what is this?)  (verify)

Fludiazepam (marketed in Japan and Taiwan under the brand name Erispan)[1][2] is a drug which is a benzodiazepine derivative and is closely related to diazepam.[3] It exerts its pharmacological properties via enhancement of GABAergic inhibition.[4] Fludiazepam has 4 times more binding affinity for benzodiazepine receptors than diazepam.[5] It possesses anxiolytic,[6][7][8] anticonvulsant, sedative, hypnotic and skeletal muscle relaxant properties.[9]

Fludiazepam is has drug abuse potential.[10]

See also

References

  1. ^ Su, TP.; Chen, TJ.; Hwang, SJ.; Chou, LF.; Fan, AP.; Chen, YC. (Aug 2002). "Utilization of psychotropic drugs in Taiwan: an overview of outpatient sector in 2000.". Zhonghua Yi Xue Za Zhi (Taipei) 65 (8): 378-91. PMID 12455808.  
  2. ^ "Benzodiazepine Names". non-benzodiazepines.org.uk. http://www.non-benzodiazepines.org.uk/benzodiazepine-names.html. Retrieved 2008-12-29.  
  3. ^ Neville, GA.; Beckstead, HD.; Shurvell, HF. (Feb 1994). "A Fourier transform-Raman and infrared vibrational study of delorazepam, fludiazepam, flurazepam, and tetrazepam.". J Pharm Sci 83 (2): 143-51. PMID 7909552.  
  4. ^ Tsuchiya, T.; Fukushima, H. (Apr 1978). "Effects of benzodiazepines and pentobarbitone on the gaba-ergic recurrent inhibition of hippocampal neurons.". Eur J Pharmacol 48 (4): 421-4. PMID 648585.  
  5. ^ Nakatsuka, I.; Shimizu, H.; Asami, Y.; Katoh, T.; Hirose, A.; Yoshitake, A. (Jan 1985). "Benzodiazepines and their metabolites: relationship between binding affinity to the benzodiazepine receptor and pharmacological activity.". Life Sci 36 (2): 113-9. PMID 2857046.  
  6. ^ Okada, S.; Ichiki, K.; Tanokuchi, S.; Ishii, K.; Hamada, H.; Ota, Z.. "Effect of an anxiolytic on lipid profile in non-insulin-dependent diabetes mellitus.". J Int Med Res 22 (6): 338-42. PMID 7895897.  
  7. ^ Okada, S.; Ichiki, K.; Tanokuchi, S.; Ishii, K.; Hamada, H.; Ota, Z.. "Improvement of stress reduces glycosylated haemoglobin levels in patients with type 2 diabetes.". J Int Med Res 23 (2): 119-22. PMID 7601294.  
  8. ^ Okada, S.; Ichiki, K.; Tanokuchi, S.; Ishii, K.; Hamada, H.; Ota, Z.. "How blood pressure in patients with non-insulin-dependent diabetes mellitus is influenced by stress.". J Int Med Res 23 (5): 377-80. PMID 8529781.  
  9. ^ Inoue, H.; Maeno, Y.; Iwasa, M.; Matoba, R.; Nagao, M. (Sep 2000). "Screening and determination of benzodiazepines in whole blood using solid-phase extraction and gas chromatography/mass spectrometry.". Forensic Sci Int 113 (1-3): 367-73. PMID 10978650.  
  10. ^ Shimamine, M.; Masunari, T.; Nakahara, Y. (1993). "[Studies on identification of drugs of abuse by diode array detection. I. Screening-test and identification of benzodiazepines by HPLC-DAD with ICOS software system]". Eisei Shikenjo Hokoku (111): 47-56. PMID 7920567.  

External links








Got something to say? Make a comment.
Your name
Your email address
Message