The Full Wiki

More info on Fludrocortisone

Fludrocortisone: Wikis

  

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

Fludrocortisone
Systematic (IUPAC) name
9-fluoro-11,17-dihydroxy-17- (2-hydroxyacetyl)- 10,13-dimethyl- 1,2,6,7,8,9,10,11,12, 13,14,15,16,17- tetradecahydrocyclopenta[a]phenanthren-3-one
Identifiers
CAS number 127-31-1
ATC code H02AA02
PubChem 31378
DrugBank APRD00756
Chemical data
Formula C 21H29FO5  
Mol. mass 380.45 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding High
Metabolism Hepatic
Half life 3.5 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat. C
Legal status
Routes oral
 Yes check.svgY(what is this?)  (verify)

Fludrocortisone (also called 9α-Flouocortisol) is a synthetic corticosteroid with moderate glucocorticoid potency and much greater mineralocorticoid potency.

The brand name in the U.S. is Florinef.

Contents

Uses

It has been used in the treatment of cerebral salt wasting.[1]

It is used primarily to replace the missing hormone aldosterone in various forms of adrenal insufficiency such as Addison's disease and the classic salt wasting (21-hydroxylase deficiency) form of congenital adrenal hyperplasia.

It is the first line of treatment for orthostatic intolerance as well.

It is also a confirmation test for diagnosing Conns Syndrome (Aldosterone producing-Adrenal adenoma), the fludrocortisone suppression test. Loading the patient with fludrocortisone would suppress serum aldosterone level in a normal patient, whereas the level will not be altered in a Conns patient.

Dosing

It is available in 0.1 mg tablets. Typical daily doses for mineralocorticoid replacement are between 0.05 mg - 0.2 mg. Renin plasma, sodium, and potassium is checked through blood tests in order to verify that the correct dosage is reached.

Chemical properties

Chemically, its structure is identical to cortisone except for the substitution of fluorine in place of one hydrogen. Fluorine is a good bioisostere for hydrogen because it is similar in size. The major difference is in its electronegativity.

Side Effects

  • Sodium and water retention
  • Swelling due to fluid retention (edema)
  • High blood pressure (hypertension)
  • Headache
  • Low blood potassium level (hypokalemia)
  • Muscle weakness
  • Fatigue
  • Increased susceptibility to infection
  • Impaired wound healing
  • Increased sweating
  • Increased hair growth (hirsutism)
  • Thinning of skin and stretch marks
  • Disturbances of the gut such as indigestion (dyspepsia), distention of the abdomen and ulceration (peptic ulcer)
  • Decreased bone density and increased risk of fractures of the bones
  • Difficulty in sleeping (insomnia)
  • Depression
  • Weight gain
  • Raised blood sugar level
  • Changes to the menstrual cycle
  • Partial loss of vision due to opacity in the lens of the eye (cataracts)
  • Raised pressure in the eye (glaucoma)
  • Increased pressure in the skull (intracranial pressure)

References








Got something to say? Make a comment.
Your name
Your email address
Message