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Flunisolide: Wikis

  

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Flunisolide
Systematic (IUPAC) name
(1S,2S,4R,8S,9 S,11S,12S,13R,19S)-19-fluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.0 2,9.04,8.013,18]icosa-14,17-dien-16-one
Identifiers
CAS number 3385-03-3
ATC code R01AD04 R03BA03
PubChem 82153
DrugBank APRD00976
Chemical data
Formula C 24H31FO6  
Mol. mass 434.498 g/mol
Synonyms 6α-Fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione acetone cyclic 16,17-acetal
Pharmacokinetic data
Bioavailability  ?
Protein binding 40% after oral inhalation
Metabolism  ?
Half life 1.8 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes Inhaled

Flunisolide (marketed as AeroBid, Nasalide, Nasarel) is a corticosteroid often prescribed as treatment for allergic rhinitis.

The principal mechanism of action of flunisolide is to activate glucocorticoid receptors. It also has anti-inflammatory action.








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