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Fluocinolone acetonide: Wikis

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Fluocinolone acetonide
Systematic (IUPAC) name
(1S,2S,4R,8S,9 S,11S,12R,13S,19S)-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.0 2,9.04,8.013,18]icosa-14,17-dien-16-one
Identifiers
CAS number 67-73-2
ATC code C05AA10 D07AC04 S01BA15 S02BA08
PubChem 6215
DrugBank APRD00977
Chemical data
Formula C 24H30F2O6  
Mol. mass 452.488 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism Hepatic, CYP3A4-mediated
Half life 1.3 to 1.7 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat. C
Legal status
Routes Topical
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Fluocinolone acetonide is a corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching. It is a synthetic hydrocortisone derivative. The fluorine substitution at position 9 in the steroid nucleus greatly enhances its activity. A typical dosage strength used in dermatology is 0.01–0.025%. One such cream is sold under the brand name Flucort-N and includes the antibiotic neomycin.

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