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Fluocinonide
Systematic (IUPAC) name
6α,9-difluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione, cyclic 16,17-acetal with acetone,21-acetate
Identifiers
CAS number 356-12-7
ATC code C05AA11 D07AC08
PubChem 9642
DrugBank APRD00978
Chemical data
Formula C 26H32F2O7  
Mol. mass 494.525 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism hepatic
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status Prescription Only (S4) (AU) POM (UK) -only (US)
Routes topical
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Fluocinonide (Fluonex, Lidex, Lidex-E, Lonide, Lyderm, and Vanos) [1] is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders such as eczema. It relieves itching, redness, dryness, crusting, scaling, inflammation, and discomfort.

The usual prescription concentration is 0.05% as a topical cream, ointment, or gel. The application area should normally not be covered after application. In certain cases, the physician may recommend the use of an occlusive dressing after application in order to increase the rate and depth of absorption. The frequency of application depends on the condition being treated and the area affected, but most often application should occur two times a day.

Fluocinonide ranks as a "high-potency" (second-highest rank) topical corticosteroid. Minimal amounts should be used for a minimal length of time to avoid the occurrence of adverse effects.[2]

Fluocinonide should not be used if infection is present. It should not be applied to the eyes or to sensitive areas such as the genitals or anus.

A common potential adverse effect is skin atrophy (thinning of the skin). Systemic absorption of topical corticosteroids can produce reversible hypothalamic-pituitary-adrenal axis (HPA) suppression, manifestations of Cushing's syndrome, hyperglycemia, and glucosuria in some patients.

Fluocinonide should be used with caution when treating children, pregnant women, nursing mothers, and anyone using the medication for longer than two weeks.

Fluocinonide is also used in veterinary medicine. It is a treatment for allergies in dogs.[3] Natural systemic cortisol concentrations can be suppressed for weeks after one week of topical exposure.[4]

References

  1. ^ MedlinePlus Drug Information: Fluocinonide Topical
  2. ^ Disease management of atopic dermatitis: a practice parameter; ANNALS OF ALLERGY, ASTHMA, & IMMUNOLOGY; VOLUME 79, SEPTEMBER, 1997; http://www.jcaai.readyportal.net/file_depot/0-10000000/20000-30000/27387/folder/63948/Atopic_Derm1997.pdf
  3. ^ Dog Allergies www.squidoo.com/dogallergy
  4. ^ Adrenocortical suppression by topically applied corticosteroids in healthy dogs. J Am Vet Med Assoc. 1987 Sep 15;191(6):685-8. http://www.ncbi.nlm.nih.gov/pubmed/2824410







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