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Systematic (IUPAC) name
CAS number 2709-56-0
ATC code N05AF01
PubChem 5281881
DrugBank APRD00388
ChemSpider 4445173
Chemical data
Formula C23H25F3N2OS
Mol. mass 434.5219 g/mol
Pharmacokinetic data
Half life 19-39 hours
Therapeutic considerations
Pregnancy cat.  ?
Legal status Prescription only
Routes Oral, IM
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Flupentixol (INN), also known as flupenthixol (former BAN), marketed under brand names such as Depixol and Fluanxol, is a typical antipsychotic drug of the thioxanthene class.



Flupentixol's main use is as a long-acting injection given two or three times weekly to individuals with schizophrenia who have poor compliance with medication and suffer frequent relapses of illness. In some countries it can be administered involuntarily under outpatient commitment laws.

Flupentixol is also used in low doses as an antidepressant.[1][2][3][4][5][6]


Flupentixol acts as an antagonist at various dopamine (D1-D5), serotonin (5-HT2), adrenaline (α1), and histamine (H1) receptors,[7] without affecting the muscarinic acetylcholine receptors.[8]

Its antipsychotic effects are likely caused by D2 and/or 5-HT2A antagonism, whereas its antidepressant effects at lower doses may be mediated by preferential D2/D3 autoreceptor blockade, resulting in increased postsynaptic activation.

Side effects

The side effects of flupentixol are similar to most other typical antipsychotics, namely extrapyramidal symptoms of akathisia, muscle tremors, and rigidity and antihistamine effects like sedation and somnolence. However, it lacks anticholinergic adverse effects.

See also


  1. ^ Robertson MM, Trimble MR (May 1981). "The antidepressant action of flupenthixol". The Practitioner 225 (1355): 761–3. PMID 7291129. 
  2. ^ Pöldinger W, Sieberns S (1983). "Depression-inducing and antidepressive effects of neuroleptics. Experiences with flupenthixol and flupenthixol decanoate". Neuropsychobiology 10 (2-3): 131–6. PMID 6674820. 
  3. ^ Johnson DA (January 1979). "A double-blind comparison of flupenthixol, nortriptyline and diazepam in neurotic depression". Acta Psychiatrica Scandinavica 59 (1): 1–8. PMID 369298. 
  4. ^ Young JP, Hughes WC, Lader MH (May 1976). "A controlled comparison of flupenthixol and amitriptyline in depressed outpatients". British Medical Journal 1 (6018): 1116–8. PMID 773506. 
  5. ^ Fujiwara J, Ishino H, Baba O, Hanaoka M, Sasaki K (August 1976). "Effect of flupenthixol on depression with special reference to combination use with tricyclic antidepressants. An uncontrolled pilot study with 45 patients". Acta Psychiatrica Scandinavica 54 (2): 99–105. PMID 961463. 
  6. ^ Tam W, Young JP, John G, Lader MH (March 1982). "A controlled comparison of flupenthixol decanoate injections and oral amitriptyline in depressed out-patients". The British Journal of Psychiatry : the Journal of Mental Science 140: 287–91. PMID 7093597. 
  7. ^ "PDSP Database - UNC". 
  8. ^ Golds PR, Przyslo FR, Strange PG (March 1980). "The binding of some antidepressant drugs to brain muscarinic acetylcholine receptors". British Journal of Pharmacology 68 (3): 541–9. PMID 7052344. 

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