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Flupirtine
Systematic (IUPAC) name
ethyl {2-amino-6-[(4-fluorobenzyl)amino]pyridin-3-yl}carbamate
Identifiers
CAS number 56995-20-1
ATC code N02BG07
PubChem 53276
Chemical data
Formula C 15H17FN4O2  
Mol. mass 304.32 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Flupirtine is an aminopyridine.

It has been used as an analgesic.[1]

It has been proposed as a possible treatment for Batten disease.[2]

It is currently under a clinical trial (recruiting phase) as a treatment for Multiple Sclerosis.[3]

References

  1. ^ Swedberg MD, Shannon HE, Nickel B, Goldberg SR (September 1988). "Pharmacological mechanisms of action of flupirtine: a novel, centrally acting, nonopioid analgesic evaluated by its discriminative effects in the rat". J. Pharmacol. Exp. Ther. 246 (3): 1067–74. PMID 2901483. http://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=2901483.  
  2. ^ Dhar S, Bitting RL, Rylova SN, et al. (April 2002). "Flupirtine blocks apoptosis in batten patient lymphoblasts and in human postmitotic CLN3- and CLN2-deficient neurons". Ann. Neurol. 51 (4): 448–66. doi:10.1002/ana.10143. PMID 11921051.  
  3. ^ [1] Flupirtine as Oral Treatment in Multiple Sclerosis (FLORIMS)







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