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Flurbiprofen: Wikis


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Systematic (IUPAC) name
(RS)-2-(2-fluorobiphenyl-4-yl)propanoic acid
CAS number 5104-49-4
ATC code M01AE09 , M02AA19, R02AX01, S01BC04
PubChem 3394
DrugBank APRD00753
Chemical data
Formula C 15H13FO2  
Mol. mass 244.261 g/mol
SMILES eMolecules & PubChem
Synonyms (±)-2-fluoro-α-methyl-(1,1'-biphenyl)-4-acetic acid
Physical data
Melt. point 117 °C (243 °F)
Pharmacokinetic data
Bioavailability  ?
Protein binding > 99%
Metabolism Hepatic (CYP2C9)
Half life 4.7-5.7 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat. C (U.S.), B2 (Au)
Legal status POM
Routes Oral
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Flurbiprofen is a member of the phenylalkanoic acid derivative family of non-steroidal anti-inflammatory drugs (NSAIDs) used to treat the inflammation and pain of arthritis. It is known by the following tradenames: Ansaid, marketed by Pfizer, and Froben, by Abbott. Flurbiprofen is also used as an active ingredient in some kinds of throat lozenges (Strepsils Intensive).

A single enantiomer of racemate flurbiprofen, tarenflurbil [(R)-flurbiprofen)], is currently in clinical trials for the treatment of metastatic prostate cancer.

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