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Flurothyl
Systematic (IUPAC) name
2,2-oxybis(1,1,1-trifluoroethane)
OR
bis(2,2,2-trifluoroethyl) ether
Identifiers
CAS number 333-36-8
ATC code none
PubChem 9528
Chemical data
Formula C 4H4F6O 
Mol. mass 182.064
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Flurothyl (Hexafluorodiethyl ether, Indoklon) is a volatile liquid drug from the halogenated ether family, related to inhaled anaesthetic agents such as diethyl ether, but having the opposite effects, acting as a stimulant and convulsant.[1] Several compounds related to the halogenated ether anesthetics have similar convulsant effects rather than producing sedation, and this has been helpful in studying the mechanism of action of these drugs.[2][3][4] Flurothyl was previously used in psychiatric medicine for shock therapy, in a similar manner to other convulsant drugs such as pentetrazol, as an alternative to electroconvulsive therapy.[5][6] This use has now been discontinued, but it is still widely used in scientific research for inducing seizures in animals.[7]

References

  1. ^ Rose L, Watson A. Flurothyl (Indoklon). Experience with an inhalational convulsant agent. Anaesthesia. 1967 Jul;22(3):425-34. PMID 4951597
  2. ^ Koblin DD, Chortkoff BS, Laster MJ, Eger EI, Halsey MJ, Ionescu P (December 1994). "Polyhalogenated and perfluorinated compounds that disobey the Meyer-Overton hypothesis". Anesthesia and Analgesia 79 (6): 1043–8. PMID 7978424.  
  3. ^ Koblin DD, Laster MJ, Ionescu P, Gong D, Eger EI, Halsey MJ, Hudlicky T (May 1999). "Polyhalogenated methyl ethyl ethers: solubilities and anesthetic properties". Anesthesia and Analgesia 88 (5): 1161–7. PMID 10320188.  
  4. ^ Eger EI, Halsey MJ, Harris RA, Koblin DD, Pohorille A, Sewell JC, Sonner JM, Trudell JR (June 1999). "Hypothesis: volatile anesthetics produce immobility by acting on two sites approximately five carbon atoms apart". Anesthesia and Analgesia 88 (6): 1395–400. PMID 10357351.  
  5. ^ A convulsant agent for psychiatric use. Flurothyl (Indoklon). Journal of the American Medical Association. 1966 Apr 4;196(1):29-30. PMID 4379572
  6. ^ Small JG, Small IF, Sharpley P, Moore DF. A double-blind comparative evaluation of flurothyl and ECT. Archives of General Psychiatry. 1968 Jul;19(1):79-86. PMID 5658383
  7. ^ Hashimoto Y, Araki H, Suemaru K, Gomita Y. Effects of drugs acting on the GABA-benzodiazepine receptor complex on flurothyl-induced seizures in Mongolian gerbils. European Journal of Pharmacology. 2006 May 1;536(3):241-7. PMID 16581068
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