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Foot-and-mouth disease virus
Foot-and-mouth disease virus-coating protein
Virus classification
Group: Group IV ((+)ssRNA)
Family: Picornaviridae
Genus: Aphthovirus
Type species
Foot-and-mouth disease virus

Foot-and-mouth disease virus is the pathogen that causes Foot-and-mouth disease.[1]

Soon after infection, the single stranded positive RNA that constitutes the viral genome is efficiently translated using a cap-independent mechanism driven by the internal ribosome entry site element (IRES). This process occurs concomitantly with the inhibition of cellular protein synthesis, caused by the expression of viral proteases. Processing of the viral polyprotein is achieved cotranslationally by viral encoded proteases, giving rise to the different mature viral proteins. Viral RNA as well as viral proteins interact with different components of the host cell, acting as key determinants of viral pathogenesis. In depth knowledge of the molecular basis of the viral cycle is needed to control viral pathogenesis and disease spreading.[2]


  1. ^ Carrillo C, Tulman ER, Delhon G, et al. (May 2005). "Comparative genomics of foot-and-mouth disease virus". J. Virol. 79 (10): 6487–504. doi:10.1128/JVI.79.10.6487-6504.2005. PMID 15858032. PMC 1091679.  
  2. ^ Martinez-Salas E, Saiz M, Sobrino F (2008). "Foot-and-Mouth Disease Virus". Animal Viruses: Molecular Biology. Caister Academic Press. pp. 1–38. ISBN 978-1-904455-22-6.  

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