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Fosaprepitant
Systematic (IUPAC) name
[3-{[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl] ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl}-5-oxo- 2H-1,2,4-triazol-1-yl]phosphonic acid
Identifiers
CAS number 172673-20-0 265121-04-8 (dimeglumine)
ATC code A04AD12
PubChem 219090
Chemical data
Formula C 23H22F7N4O6P 
Mol. mass 614.406 g/mol
Pharmacokinetic data
Bioavailability n/a
Protein binding >95% (aprepitant)
Metabolism To aprepitant
Half life 9 to 13 hours (aprepitant)
Excretion  ?
Therapeutic considerations
Licence data

EU EMEA:linkUS FDA:link

Pregnancy cat. B(US)
Legal status -only (US)
Routes Intravenous

Fosaprepitant (Emend for Injection (US), Ivemend (EU)) is an antiemetic drug, administered intravenously. It is a prodrug of aprepitant.

Fosaprepitant was developed by Merck & Co. and was approved by the United States Food and Drug Administration (FDA) on January 25, 2008.[1] and by the European Medicines Agency (EMA) on January 11 of the same year.[2]

See also

References








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