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Free fatty acid receptor 1
Identifiers
Symbols FFAR1; FFA1R; GPR40
External IDs OMIM603820 MGI2684079 HomoloGene3876 IUPHAR: FFA1 GeneCards: FFAR1 Gene
Orthologs
Species Human Mouse
Entrez 2864 233081
Ensembl ENSG00000126266 ENSMUSG00000044453
UniProt O14842 Q76JU9
RefSeq (mRNA) NM_005303 NM_194057
RefSeq (protein) NP_005294 NP_918946
Location (UCSC) Chr 19:
40.53 - 40.54 Mb
Chr 7:
30.57 - 30.57 Mb
PubMed search [1] [2]

Free fatty acid receptor 1, (FFA1) is a G-protein coupled receptor encoded by the human gene FFAR1.[1] It is strongly expressed in the cells of the pancreas, but also, to a lesser extent, the uterus and brain[2].

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Further reading

  • Brown AJ, Jupe S, Briscoe CP (2005). "A family of fatty acid binding receptors.". DNA Cell Biol. 24 (1): 54–61. doi:10.1089/dna.2005.24.54. PMID 15684720.  
  • Sawzdargo M, George SR, Nguyen T, et al. (1997). "A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1.". Biochem. Biophys. Res. Commun. 239 (2): 543–7. doi:10.1006/bbrc.1997.7513. PMID 9344866.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Briscoe CP, Tadayyon M, Andrews JL, et al. (2003). "The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids.". J. Biol. Chem. 278 (13): 11303–11. doi:10.1074/jbc.M211495200. PMID 12496284.  
  • Kotarsky K, Nilsson NE, Flodgren E, et al. (2003). "A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs.". Biochem. Biophys. Res. Commun. 301 (2): 406–10. doi:10.1016/S0006-291X(02)03064-4. PMID 12565875.  
  • Itoh Y, Kawamata Y, Harada M, et al. (2003). "Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40.". Nature 422 (6928): 173–6. doi:10.1038/nature01478. PMID 12629551.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Hardy S, St-Onge GG, Joly E, et al. (2005). "Oleate promotes the proliferation of breast cancer cells via the G protein-coupled receptor GPR40.". J. Biol. Chem. 280 (14): 13285–91. doi:10.1074/jbc.M410922200. PMID 15695516.  
  • Ogawa T, Hirose H, Miyashita K, et al. (2005). "GPR40 gene Arg211His polymorphism may contribute to the variation of insulin secretory capacity in Japanese men.". Metab. Clin. Exp. 54 (3): 296–9. doi:10.1016/j.metabol.2004.09.008. PMID 15736105.  
  • Tomita T, Masuzaki H, Noguchi M, et al. (2006). "GPR40 gene expression in human pancreas and insulinoma.". Biochem. Biophys. Res. Commun. 338 (4): 1788–90. doi:10.1016/j.bbrc.2005.10.161. PMID 16289108.  
  • Tomita T, Masuzaki H, Iwakura H, et al. (2006). "Expression of the gene for a membrane-bound fatty acid receptor in the pancreas and islet cell tumours in humans: evidence for GPR40 expression in pancreatic beta cells and implications for insulin secretion.". Diabetologia 49 (5): 962–8. doi:10.1007/s00125-006-0193-8. PMID 16525841.  
  • Stoddart LA, Brown AJ, Milligan G (2007). "Uncovering the pharmacology of the G protein-coupled receptor GPR40: high apparent constitutive activity in guanosine 5'-O-(3-[35S]thio)triphosphate binding studies reflects binding of an endogenous agonist.". Mol. Pharmacol. 71 (4): 994–1005. doi:10.1124/mol.106.031534. PMID 17200419.  
  • Bartoov-Shifman R, Ridner G, Bahar K, et al. (2007). "Regulation of the gene encoding GPR40, a fatty acid receptor expressed selectively in pancreatic beta cells.". J. Biol. Chem. 282 (32): 23561–71. doi:10.1074/jbc.M702115200. PMID 17525159.  
  • Sum CS, Tikhonova IG, Neumann S, et al. (2007). "Identification of residues important for agonist recognition and activation in GPR40.". J. Biol. Chem. 282 (40): 29248–55. doi:10.1074/jbc.M705077200. PMID 17699519.  
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