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Fructose 1,6-bisphosphate
CAS number 488-69-7
PubChem 172313
MeSH fructose-1,6-diphosphate
Molecular formula C6H14O12P2
Molar mass 340.116
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Fructose 1,6-biphosphate (also known as Harden-young ester)is fructose sugar phosphorylated on carbons 1 and 6 (ie. is a fructosephosphate). The β-D-form of this compound is very common in cells. The vast majority of glucose and fructose entering a cell will become converted to fructose 1,6-biphosphate at some point.

Fructose 1,6-bisphosphate in glycolysis

Fructose 1,6-bisphosphate lies within the glycolysis metabolic pathway and is produced by phosphorylation of fructose 6-phosphate. It is in turn broken down into two compounds; glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. It is an allosteric activator of pyruvate kinase.

β-D-fructose 6-phosphate 6-phosphofructo 1-kinase β-D-fructose 1,6-phosphate Fructose bisphosphate aldolase D-glyceraldehyde 3-phosphate dihydroxyacetone phosphate
Beta-D-fructose-6-phosphate wpmp.png Beta-D-fructose-1,6-bisphosphate wpmp.png D-glyceraldehyde-3-phosphate wpmp.png + Glycerone-phosphate wpmp.png
Biochem reaction arrow reversible YYYY horiz med.png Biochem reaction arrow reversible NNNN horiz med.png
Pi H2O
Hexose diphosphatase Fructose bisphosphate aldolase

Compound C05345 at KEGG Pathway Database. Enzyme at KEGG Pathway Database. Enzyme at KEGG Pathway Database. Compound C05378 at KEGG Pathway Database. Enzyme at KEGG Pathway Database. Compound C00111 at KEGG Pathway Database. Compound C00118 at KEGG Pathway Database.

The numbering of the carbon atoms indicates the fate of the carbons according to their position in fructose 6-phosphate.

Fructose 1,6-phosphate isomerism

Fructose 1,6-phosphate has only one biologically active isomer, the β-D-form. There are many other isomers, analogous to those of fructose.

See also



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