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Systematic (IUPAC) name
CAS number 67-45-8
ATC code G01AX06
PubChem 5323714
DrugBank DB00614
Chemical data
Formula C 8H7N3O5  
Mol. mass 225.16
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes Oral-Local
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Furazolidone is an antibacterial. It is marketed by Roberts Laboratories under the brand name Furoxone and by GlaxoSmithKline as Dependal-M.



It is used to treat diarrhoea and enteritis caused by bacteria or protozoan infections.

It has been used in aquaculture.[1]


Furazolidone is also used for Giardiasis (due to Giardia lamblia), though it is not a first line treatment.[2]


Furazolidone is also used to treat traveler's diarrhoea, cholera, and bacteremic salmonellosis.

As a veterinary medicine, furazolidone has been used with some success to treat salmonids for Myxobolus cerebralis infections.

Use in treating Helicobacter pylori infections has been proposed.[3]


It is believed to work by crosslinking of DNA. [4]

Side effects

Furazolidone is no longer available in the US. Though an effective antibiotic when all others fail, against extremely drug resistant infections, it has many side effects, and as with other nitrofurans generally, minimum inhibitory concentrations also produce systemic toxicity (tremors, convulsions, periferal neuritis, gastrointestinal disturbances, depression of spermatogenesis.) Nitrofurans are recognized by FDA as mutagens/carcinogens, and can no longer be used since 1991. [5]


  1. ^ Meng J, Mangat SS, Grudzinski IP, Law FC (1998). "Evidence of 14C-furazolidone metabolite binding to the hepatic DNA of trout". Drug Metabol Drug Interact 14 (4): 209–19. PMID 10694929.  
  2. ^ Petri WA (February 2005). "Treatment of Giardiasis". Curr Treat Options Gastroenterol 8 (1): 13–17. PMID 15625030.  
  3. ^ Machado RS, Silva MR, Viriato A (2008). "Furazolidone, tetracycline and omeprazole: a low-cost alternative for Helicobacter pylori eradication in children". Jornal de pediatria 84 (2): 160–5. doi:doi:10.2223/JPED.1772. PMID 18372934.  
  4. ^ "DrugBank: Showing Furazolidone (DB00614)". Retrieved 2008-12-19.  
  5. ^

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