The Full Wiki

More info on GABA transporter

GABA transporter: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

(Redirected to GABA transporter 1 article)

From Wikipedia, the free encyclopedia

edit
Solute carrier family 6 (neurotransmitter transporter, GABA), member 1
Identifiers
Symbols SLC6A1; GABATHG; GABATR; GAT1
External IDs OMIM137165 MGI95627 HomoloGene2290 GeneCards: SLC6A1 Gene
RNA expression pattern
PBB GE SLC6A1 205152 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6529 232333
Ensembl ENSG00000157103 ENSMUSG00000030310
UniProt P30531 Q6PCX2
RefSeq (mRNA) NM_003042 XM_975926
RefSeq (protein) NP_003033 XP_981020
Location (UCSC) Chr 3:
11.01 - 11.06 Mb
Chr 6:
114.25 - 114.28 Mb
PubMed search [1] [2]

GABA transporter 1 (GAT-1) also known as sodium- and chloride-dependent GABA transporter 1 is a protein that in humans is encoded by the SLC6A1 gene.[1][2]

Contents

Function

GAT-1 a gamma-aminobutyric acid (GABA) transporter, which removes GABA from the synaptic cleft.[3]

Interactions

SLC6A1 has been shown to interact with STX1A.[4][5][6]

See also

References

  1. ^ Huang F, Shi LJ, Heng HH, Fei J, Guo LH (Feb 1996). "Assignment of the human GABA transporter gene (GABATHG) locus to chromosome 3p24-p25". Genomics 29 (1): 302–4. doi:10.1006/geno.1995.1253. PMID 8530094.  
  2. ^ "Entrez Gene: SLC6A1 solute carrier family 6 (neurotransmitter transporter, GABA), member 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6529.  
  3. ^ Hirunsatit R, George ED, Lipska BK, Elwafi HM, Sander L, Yrigollen CM, Gelernter J, Grigorenko EL, Lappalainen J, Mane S, Nairn AC, Kleinman JE, Simen AA (January 2009). "Twenty-one-base-pair insertion polymorphism creates an enhancer element and potentiates SLC6A1 GABA transporter promoter activity". Pharmacogenet. Genomics 19 (1): 53–65. doi:10.1097/FPC.0b013e328318b21a. PMID 19077666.  
  4. ^ Beckman, M L; Bernstein E M, Quick M W (Aug. 1998). "Protein kinase C regulates the interaction between a GABA transporter and syntaxin 1A". J. Neurosci. (UNITED STATES) 18 (16): 6103–12. ISSN 0270-6474. PMID 9698305.  
  5. ^ Quick, Michael W (Apr. 2002). "Substrates regulate gamma-aminobutyric acid transporters in a syntaxin 1A-dependent manner". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (8): 5686–91. doi:10.1073/pnas.082712899. ISSN 0027-8424. PMID 11960023.  
  6. ^ Deken, S L; Beckman M L, Boos L, Quick M W (Oct. 2000). "Transport rates of GABA transporters: regulation by the N-terminal domain and syntaxin 1A". Nat. Neurosci. (UNITED STATES) 3 (10): 998–1003. doi:10.1038/79939. ISSN 1097-6256. PMID 11017172.  

Further reading

  • Nelson H, Mandiyan S, Nelson N (1990). "Cloning of the human brain GABA transporter.". FEBS Lett. 269 (1): 181–4. doi:10.1016/0014-5793(90)81149-I. PMID 2387399.  
  • Bennett ER, Kanner BI (1997). "The membrane topology of GAT-1, a (Na+ + Cl-)-coupled gamma-aminobutyric acid transporter from rat brain.". J. Biol. Chem. 272 (2): 1203–10. doi:10.1074/jbc.272.2.1203. PMID 8995422.  
  • Bismuth Y, Kavanaugh MP, Kanner BI (1997). "Tyrosine 140 of the gamma-aminobutyric acid transporter GAT-1 plays a critical role in neurotransmitter recognition.". J. Biol. Chem. 272 (26): 16096–102. doi:10.1074/jbc.272.26.16096. PMID 9195904.  
  • DeFelipe J, González-Albo MC (1998). "Chandelier cell axons are immunoreactive for GAT-1 in the human neocortex.". Neuroreport 9 (3): 467–70. doi:10.1097/00001756-199802160-00020. PMID 9512391.  
  • Conti F, Melone M, De Biasi S, et al. (1998). "Neuronal and glial localization of GAT-1, a high-affinity gamma-aminobutyric acid plasma membrane transporter, in human cerebral cortex: with a note on its distribution in monkey cortex.". J. Comp. Neurol. 396 (1): 51–63. doi:10.1002/(SICI)1096-9861(19980622)396:1<51::AID-CNE5>3.0.CO;2-H. PMID 9623887.  
  • Beckman ML, Bernstein EM, Quick MW (1998). "Protein kinase C regulates the interaction between a GABA transporter and syntaxin 1A.". J. Neurosci. 18 (16): 6103–12. PMID 9698305.  
  • Augood SJ, Waldvogel HJ, Münkle MC, et al. (1999). "Localization of calcium-binding proteins and GABA transporter (GAT-1) messenger RNA in the human subthalamic nucleus.". Neuroscience 88 (2): 521–34. doi:10.1016/S0306-4522(98)00226-7. PMID 10197772.  
  • Ong WY, Yeo TT, Balcar VJ, Garey LJ (2000). "A light and electron microscopic study of GAT-1-positive cells in the cerebral cortex of man and monkey.". J. Neurocytol. 27 (10): 719–30. doi:10.1023/A:1006946717065. PMID 10640187.  
  • Deken SL, Beckman ML, Boos L, Quick MW (2000). "Transport rates of GABA transporters: regulation by the N-terminal domain and syntaxin 1A.". Nat. Neurosci. 3 (10): 998–1003. doi:10.1038/79939. PMID 11017172.  
  • Whitworth TL, Quick MW (2001). "Substrate-induced regulation of gamma-aminobutyric acid transporter trafficking requires tyrosine phosphorylation.". J. Biol. Chem. 276 (46): 42932–7. doi:10.1074/jbc.M107638200. PMID 11555659.  
  • Hachiya Y, Takashima S (2002). "Development of GABAergic neurons and their transporter in human temporal cortex.". Pediatr. Neurol. 25 (5): 390–6. doi:10.1016/S0887-8994(01)00348-4. PMID 11744314.  
  • Quick MW (2002). "Substrates regulate gamma-aminobutyric acid transporters in a syntaxin 1A-dependent manner.". Proc. Natl. Acad. Sci. U.S.A. 99 (8): 5686–91. doi:10.1073/pnas.082712899. PMID 11960023.  
  • Kanner BI (2003). "Transmembrane domain I of the gamma-aminobutyric acid transporter GAT-1 plays a crucial role in the transition between cation leak and transport modes.". J. Biol. Chem. 278 (6): 3705–12. doi:10.1074/jbc.M210525200. PMID 12446715.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Zomot E, Kanner BI (2003). "The interaction of the gamma-aminobutyric acid transporter GAT-1 with the neurotransmitter is selectively impaired by sulfhydryl modification of a conformationally sensitive cysteine residue engineered into extracellular loop IV.". J. Biol. Chem. 278 (44): 42950–8. doi:10.1074/jbc.M209307200. PMID 12925537.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Zhou Y, Bennett ER, Kanner BI (2004). "The aqueous accessibility in the external half of transmembrane domain I of the GABA transporter GAT-1 Is modulated by its ligands.". J. Biol. Chem. 279 (14): 13800–8. doi:10.1074/jbc.M311579200. PMID 14744863.  
  • Hu JH, Ma YH, Jiang J, et al. (2004). "Cognitive impairment in mice over-expressing gamma-aminobutyric acid transporter 1 (GAT1).". Neuroreport 15 (1): 9–12. doi:10.1097/00001756-200401190-00003. PMID 15106822.  
  • Korkhov VM, Farhan H, Freissmuth M, Sitte HH (2005). "Oligomerization of the {gamma}-aminobutyric acid transporter-1 is driven by an interplay of polar and hydrophobic interactions in transmembrane helix II.". J. Biol. Chem. 279 (53): 55728–36. doi:10.1074/jbc.M409449200. PMID 15496410.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message