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Gamma-aminobutyric acid (GABA) B receptor, 2
Symbols GABBR2; FLJ36928; GABABR2; GPR51; GPRC3B; HG20
External IDs OMIM607340 MGI2386030 HomoloGene55902 IUPHAR: GABAB2 GeneCards: GABBR2 Gene
RNA expression pattern
PBB GE GABBR2 209990 s at tn.png
PBB GE GABBR2 209991 x at tn.png
PBB GE GABBR2 211679 x at tn.png
More reference expression data
Species Human Mouse
Entrez 9568 242425
Ensembl ENSG00000136928 n/a
UniProt O75899 n/a
RefSeq (mRNA) NM_005458 XM_143750
RefSeq (protein) NP_005449 XP_143750
Location (UCSC) Chr 9:
100.09 - 100.51 Mb
PubMed search [1] [2]

Gamma-aminobutyric acid (GABA) B receptor, 2 (GABAB2) is a G-protein coupled receptor subunit encoded by the GABBR2 gene in humans.[1]

B-type receptors for the neurotransmitter GABA (gamma-aminobutyric acid) inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters and the activity of ion channels and adenylyl cyclase. See GABBR1 (MIM 603540) for additional background information on GABA-B receptors.[supplied by OMIM][1]



GABBR2 has been shown to interact with GABBR1.[2]

See also


  1. ^ a b "Entrez Gene: GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2".  
  2. ^ White, J H; Wise A, Main M J, Green A, Fraser N J, Disney G H, Barnes A A, Emson P, Foord S M, Marshall F H (Dec. 1998). "Heterodimerization is required for the formation of a functional GABA(B) receptor". Nature (ENGLAND) 396 (6712): 679–82. doi:10.1038/25354. ISSN 0028-0836. PMID 9872307.  

External links

Further reading

  • White JH, Wise A, Main MJ, et al. (1999). "Heterodimerization is required for the formation of a functional GABA(B) receptor.". Nature 396 (6712): 679–82. doi:10.1038/25354. PMID 9872316.  
  • Ng GY, Clark J, Coulombe N, et al. (1999). "Identification of a GABAB receptor subunit, gb2, required for functional GABAB receptor activity.". J. Biol. Chem. 274 (12): 7607–10. doi:10.1074/jbc.274.12.7607. PMID 10075644.  
  • Ng GY, McDonald T, Bonnert T, et al. (1999). "Cloning of a novel G-protein-coupled receptor GPR 51 resembling GABAB receptors expressed predominantly in nervous tissues and mapped proximal to the hereditary sensory neuropathy type 1 locus on chromosome 9.". Genomics 56 (3): 288–95. doi:10.1006/geno.1998.5706. PMID 10087195.  
  • Martin SC, Russek SJ, Farb DH (1999). "Molecular identification of the human GABABR2: cell surface expression and coupling to adenylyl cyclase in the absence of GABABR1.". Mol. Cell. Neurosci. 13 (3): 180–91. doi:10.1006/mcne.1999.0741. PMID 10328880.  
  • Clark JA, Mezey E, Lam AS, Bonner TI (2000). "Distribution of the GABA(B) receptor subunit gb2 in rat CNS.". Brain Res. 860 (1-2): 41–52. doi:10.1016/S0006-8993(00)01958-2. PMID 10727622.  
  • Sullivan R, Chateauneuf A, Coulombe N, et al. (2000). "Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor.". J. Pharmacol. Exp. Ther. 293 (2): 460–7. PMID 10773016.  
  • White JH, McIllhinney RA, Wise A, et al. (2001). "The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx.". Proc. Natl. Acad. Sci. U.S.A. 97 (25): 13967–72. doi:10.1073/pnas.240452197. PMID 11087824.  
  • Kitano J, Kimura K, Yamazaki Y, et al. (2002). "Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins.". J. Neurosci. 22 (4): 1280–9. PMID 11850456.  
  • Salim K, Fenton T, Bacha J, et al. (2002). "Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation.". J. Biol. Chem. 277 (18): 15482–5. doi:10.1074/jbc.M201539200. PMID 11854302.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Furtinger S, Pirker S, Czech T, et al. (2004). "Increased expression of gamma-aminobutyric acid type B receptors in the hippocampus of patients with temporal lobe epilepsy.". Neurosci. Lett. 352 (2): 141–5. doi:10.1016/j.neulet.2003.08.046. PMID 14625043.  
  • Waldvogel HJ, Billinton A, White JH, et al. (2004). "Comparative cellular distribution of GABAA and GABAB receptors in the human basal ganglia: immunohistochemical colocalization of the alpha 1 subunit of the GABAA receptor, and the GABABR1 and GABABR2 receptor subunits.". J. Comp. Neurol. 470 (4): 339–56. doi:10.1002/cne.20005. PMID 14961561.  
  • Balasubramanian S, Teissére JA, Raju DV, Hall RA (2004). "Hetero-oligomerization between GABAA and GABAB receptors regulates GABAB receptor trafficking.". J. Biol. Chem. 279 (18): 18840–50. doi:10.1074/jbc.M313470200. PMID 14966130.  
  • Uezono Y, Kaibara M, Hayashi H, et al. (2004). "Characterization of GABAB receptor in the human colon.". J. Pharmacol. Sci. 94 (2): 211–3. doi:10.1254/jphs.94.211. PMID 14978362.  
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMID 15164053.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Hlavackova V, Goudet C, Kniazeff J, et al. (2005). "Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR.". EMBO J. 24 (3): 499–509. doi:10.1038/sj.emboj.7600557. PMID 15660124.  
  • DeGiorgis JA, Jaffe H, Moreira JE, et al. (2005). "Phosphoproteomic analysis of synaptosomes from human cerebral cortex.". J. Proteome Res. 4 (2): 306–15. doi:10.1021/pr0498436. PMID 15822905.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
  • Osawa Y, Xu D, Sternberg D, et al. (2006). "Functional expression of the GABAB receptor in human airway smooth muscle.". Am. J. Physiol. Lung Cell Mol. Physiol. 291 (5): L923–31. doi:10.1152/ajplung.00185.2006. PMID 16829628.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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