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Gamma-aminobutyric acid (GABA) A receptor, alpha 4
Identifiers
Symbols GABRA4;
External IDs OMIM137141 MGI95616 HomoloGene631 GeneCards: GABRA4 Gene
RNA expression pattern
PBB GE GABRA4 208463 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2557 14397
Ensembl ENSG00000109158 n/a
UniProt P48169 n/a
RefSeq (mRNA) NM_000809 NM_010251
RefSeq (protein) NP_000800 NP_034381
Location (UCSC) Chr 4:
46.62 - 46.69 Mb
n/a
PubMed search [1] [2]

Gamma-aminobutyric acid receptor subunit alpha-4 is a protein that in humans is encoded by the GABRA4 gene.[1][2]

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified.[2]

Contents

See also

References

  1. ^ McLean PJ, Farb DH, Russek SJ (Aug 1995). "Mapping of the alpha 4 subunit gene (GABRA4) to human chromosome 4 defines an alpha 2-alpha 4-beta 1-gamma 1 gene cluster: further evidence that modern GABAA receptor gene clusters are derived from an ancestral cluster". Genomics 26 (3): 580-6. PMID 7607683.  
  2. ^ a b "Entrez Gene: GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2557.  

Further reading

  • Tögel M, Mossier B, Fuchs K, Sieghart W (1994). "gamma-Aminobutyric acidA receptors displaying association of gamma 3-subunits with beta 2/3 and different alpha-subunits exhibit unique pharmacological properties.". J. Biol. Chem. 269 (17): 12993–8. PMID 8175718.  
  • Yang W, Drewe JA, Lan NC (1996). "Cloning and characterization of the human GABAA receptor alpha 4 subunit: identification of a unique diazepam-insensitive binding site.". Eur. J. Pharmacol. 291 (3): 319–25. PMID 8719416.  
  • Kumar R, Lumsden A, Ciclitira PJ, et al. (2000). "Human genome search in celiac disease using gliadin cDNA as probe.". J. Mol. Biol. 300 (5): 1155–67. doi:10.1006/jmbi.2000.3927. PMID 10903861.  
  • Kumar S, Sieghart W, Morrow AL (2002). "Association of protein kinase C with GABA(A) receptors containing alpha1 and alpha4 subunits in the cerebral cortex: selective effects of chronic ethanol consumption.". J. Neurochem. 82 (1): 110–7. doi:10.1046/j.1471-4159.2002.00943.x. PMID 12091471.  
  • Mu W, Cheng Q, Yang J, Burt DR (2002). "Alternative splicing of the GABA(A) receptor alpha 4 subunit creates a severely truncated mRNA.". Brain Res. Bull. 58 (5): 447–54. doi:10.1016/S0361-9230(02)00816-X. PMID 12242096.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Ma DQ, Whitehead PL, Menold MM, et al. (2006). "Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism.". Am. J. Hum. Genet. 77 (3): 377–88. doi:10.1086/433195. PMID 16080114.  
  • Collins AL, Ma D, Whitehead PL, et al. (2007). "Investigation of autism and GABA receptor subunit genes in multiple ethnic groups.". Neurogenetics 7 (3): 167–74. doi:10.1007/s10048-006-0045-1. PMID 16770606.  
  • Lagrange AH, Botzolakis EJ, Macdonald RL (2007). "Enhanced macroscopic desensitization shapes the response of alpha4 subtype-containing GABAA receptors to synaptic and extrasynaptic GABA.". J. Physiol. (Lond.) 578 (Pt 3): 655–76. doi:10.1113/jphysiol.2006.122135. PMID 17124266.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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