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Gamma-aminobutyric acid (GABA) A receptor, pi
Symbols GABRP; MGC126386; MGC126387
External IDs OMIM602729 MGI2387597 HomoloGene22798 GeneCards: GABRP Gene
RNA expression pattern
PBB GE GABRP 205044 at tn.png
More reference expression data
Species Human Mouse
Entrez 2568 216643
Ensembl ENSG00000094755 ENSMUSG00000020159
UniProt O00591 Q8K367
RefSeq (mRNA) NM_014211 NM_146017
RefSeq (protein) NP_055026 NP_666129
Location (UCSC) Chr 5:
170.14 - 170.17 Mb
Chr 11:
33.45 - 33.48 Mb
PubMed search [1] [2]

Gamma-aminobutyric acid receptor subunit pi is a protein that in humans is encoded by the GABRP gene.[1][2]

The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. The subunit encoded by this gene is expressed in several non-neuronal tissues including the uterus and ovaries. This subunit can assemble with known GABA A receptor subunits, and the presence of this subunit alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone.[2]


See also


  1. ^ Hedblom E, Kirkness EF (Jul 1997). "A novel class of GABAA receptor subunit in tissues of the reproductive system". J Biol Chem 272 (24): 15346-50. PMID 9182563.  
  2. ^ a b "Entrez Gene: GABRP gamma-aminobutyric acid (GABA) A receptor, pi".  

Further reading

  • Mehta AK, Ticku MK (1999). "An update on GABAA receptors.". Brain Res. Brain Res. Rev. 29 (2-3): 196–217. doi:10.1016/S0165-0173(98)00052-6. PMID 10209232.  
  • Zafrakas M, Chorovicer M, Klaman I, et al. (2007). "Systematic characterisation of GABRP expression in sporadic breast cancer and normal breast tissue.". Int. J. Cancer 118 (6): 1453–9. doi:10.1002/ijc.21517. PMID 16187283.  
  • Petryshen TL, Middleton FA, Tahl AR, et al. (2006). "Genetic investigation of chromosome 5q GABAA receptor subunit genes in schizophrenia.". Mol. Psychiatry 10 (12): 1074–88, 1057. doi:10.1038/ PMID 16172613.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Galey D, Becker K, Haughey N, et al. (2003). "Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes.". J. Neurovirol. 9 (3): 358–71. doi:10.1080/713831545. PMID 12775419.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Neelands TR, Macdonald RL (1999). "Incorporation of the pi subunit into functional gamma-aminobutyric Acid(A) receptors.". Mol. Pharmacol. 56 (3): 598–610. PMID 10462548.  
  • Taylor PM, Thomas P, Gorrie GH, et al. (1999). "Identification of amino acid residues within GABA(A) receptor beta subunits that mediate both homomeric and heteromeric receptor expression.". J. Neurosci. 19 (15): 6360–71. PMID 10414965.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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