The Full Wiki

More info on GABRR1

GABRR1: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

edit
Gamma-aminobutyric acid (GABA) receptor, rho 1
Identifiers
Symbols GABRR1; MGC163216
External IDs OMIM137161 MGI95625 HomoloGene20470 GeneCards: GABRR1 Gene
RNA expression pattern
PBB GE GABRR1 206525 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2569 14408
Ensembl ENSG00000146276 ENSMUSG00000028280
UniProt P24046 P56475
RefSeq (mRNA) NM_002042 NM_008075
RefSeq (protein) NP_002033 NP_032101
Location (UCSC) Chr 6:
89.94 - 89.98 Mb
Chr 4:
33.46 - 33.49 Mb
PubMed search [1] [2]

Gamma-aminobutyric acid receptor subunit rho-1 is a protein that in humans is encoded by the GABRR1 gene.[1][2][3]

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. GABRR1 is a member of the rho subunit family.[3]

Contents

See also

References

  1. ^ Cutting GR, Lu L, O'Hara BF, Kasch LM, Montrose-Rafizadeh C, Donovan DM, Shimada S, Antonarakis SE, Guggino WB, Uhl GR, et al. (May 1991). "Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina". Proc Natl Acad Sci U S A 88 (7): 2673-7. PMID 1849271.  
  2. ^ Cutting GR, Curristin S, Zoghbi H, O'Hara B, Seldin MF, Uhl GR (May 1992). "Identification of a putative gamma-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4". Genomics 12 (4): 801-6. PMID 1315307.  
  3. ^ a b "Entrez Gene: GABRR1 gamma-aminobutyric acid (GABA) receptor, rho 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2569.  

Further reading

  • Wang TL, Hackam A, Guggino WB, Cutting GR (1995). "A single histidine residue is essential for zinc inhibition of GABA rho 1 receptors.". J. Neurosci. 15 (11): 7684–91. PMID 7472519.  
  • Hackam AS, Wang TL, Guggino WB, Cutting GR (1997). "The N-terminal domain of human GABA receptor rho1 subunits contains signals for homooligomeric and heterooligomeric interaction.". J. Biol. Chem. 272 (21): 13750–7. doi:10.1074/jbc.272.21.13750. PMID 9153229.  
  • Kusama T, Hatama K, Sakurai M, et al. (1999). "Consensus phosphorylation sites of human GABA(c)/GABArho receptors are not critical for inhibition by protein kinase C activation.". Neurosci. Lett. 255 (1): 17–20. doi:10.1016/S0304-3940(98)00696-X. PMID 9839716.  
  • Hanley JG, Koulen P, Bedford F, et al. (1999). "The protein MAP-1B links GABA(C) receptors to the cytoskeleton at retinal synapses.". Nature 397 (6714): 66–9. doi:10.1038/16258. PMID 9892354.  
  • Bailey ME, Albrecht BE, Johnson KJ, Darlison MG (1999). "Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3.". Biochim. Biophys. Acta 1447 (2-3): 307–12. PMID 10542332.  
  • Hanley JG, Jones EM, Moss SJ (2000). "GABA receptor rho1 subunit interacts with a novel splice variant of the glycine transporter, GLYT-1.". J. Biol. Chem. 275 (2): 840–6. doi:10.1074/jbc.275.2.840. PMID 10625616.  
  • Filippova N, Sedelnikova A, Zong Y, et al. (2000). "Regulation of recombinant gamma-aminobutyric acid (GABA)(A) and GABA(C) receptors by protein kinase C.". Mol. Pharmacol. 57 (5): 847–56. PMID 10779366.  
  • Billups D, Hanley JG, Orme M, et al. (2001). "GABAC receptor sensitivity is modulated by interaction with MAP1B.". J. Neurosci. 20 (23): 8643–50. PMID 11102469.  
  • Wang QW, Li ZW, Wang F, Yang JQ (2002). "Modulation by divalent cations of GABA rho 1 receptor from human retina expressed in Xenopus oocytes.". Biomed. Environ. Sci. 14 (4): 269–77. PMID 11862606.  
  • Sedelnikova A, Weiss DS (2002). "Phosphorylation of the recombinant rho1 GABA receptor.". Int. J. Dev. Neurosci. 20 (3-5): 237–46. doi:10.1016/S0736-5748(02)00037-0. PMID 12175859.  
  • Torres VI, Weiss DS (2003). "Identification of a tyrosine in the agonist binding site of the homomeric rho1 gamma-aminobutyric acid (GABA) receptor that, when mutated, produces spontaneous opening.". J. Biol. Chem. 277 (46): 43741–8. doi:10.1074/jbc.M202007200. PMID 12226075.  
  • Croci C, Brändstatter JH, Enz R (2003). "ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2.". J. Biol. Chem. 278 (8): 6128–35. doi:10.1074/jbc.M205162200. PMID 12431995.  
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.  
  • Boué-Grabot E, Emerit MB, Toulmé E, et al. (2004). "Cross-talk and co-trafficking between rho1/GABA receptors and ATP-gated channels.". J. Biol. Chem. 279 (8): 6967–75. doi:10.1074/jbc.M307772200. PMID 14660627.  
  • Martínez-Torres A, Miledi R (2004). "A single amino acid change within the ion-channel domain of the gamma-aminobutyric acid rho1 receptor accelerates desensitization and increases taurine agonism.". Arch. Med. Res. 35 (3): 194–8. doi:10.1016/j.arcmed.2003.12.002. PMID 15163459.  
  • Sedelnikova A, Smith CD, Zakharkin SO, et al. (2005). "Mapping the rho1 GABA(C) receptor agonist binding pocket. Constructing a complete model.". J. Biol. Chem. 280 (2): 1535–42. doi:10.1074/jbc.M409908200. PMID 15548535.  
  • Song XQ, Meng F, Ramsey DJ, et al. (2006). "The GABA rho1 subunit interacts with a cellular retinoic acid binding protein in mammalian retina.". Neuroscience 136 (2): 467–75. doi:10.1016/j.neuroscience.2005.08.018. PMID 16198491.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message