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Gamma-aminobutyric acid (GABA) receptor, rho 1
Symbols GABRR1; MGC163216
External IDs OMIM137161 MGI95625 HomoloGene20470 GeneCards: GABRR1 Gene
RNA expression pattern
PBB GE GABRR1 206525 at tn.png
More reference expression data
Species Human Mouse
Entrez 2569 14408
Ensembl ENSG00000146276 ENSMUSG00000028280
UniProt P24046 P56475
RefSeq (mRNA) NM_002042 NM_008075
RefSeq (protein) NP_002033 NP_032101
Location (UCSC) Chr 6:
89.94 - 89.98 Mb
Chr 4:
33.46 - 33.49 Mb
PubMed search [1] [2]

Gamma-aminobutyric acid receptor subunit rho-1 is a protein that in humans is encoded by the GABRR1 gene.[1][2][3]

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. GABRR1 is a member of the rho subunit family.[3]


See also


  1. ^ Cutting GR, Lu L, O'Hara BF, Kasch LM, Montrose-Rafizadeh C, Donovan DM, Shimada S, Antonarakis SE, Guggino WB, Uhl GR, et al. (May 1991). "Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina". Proc Natl Acad Sci U S A 88 (7): 2673-7. PMID 1849271.  
  2. ^ Cutting GR, Curristin S, Zoghbi H, O'Hara B, Seldin MF, Uhl GR (May 1992). "Identification of a putative gamma-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4". Genomics 12 (4): 801-6. PMID 1315307.  
  3. ^ a b "Entrez Gene: GABRR1 gamma-aminobutyric acid (GABA) receptor, rho 1".  

Further reading

  • Wang TL, Hackam A, Guggino WB, Cutting GR (1995). "A single histidine residue is essential for zinc inhibition of GABA rho 1 receptors.". J. Neurosci. 15 (11): 7684–91. PMID 7472519.  
  • Hackam AS, Wang TL, Guggino WB, Cutting GR (1997). "The N-terminal domain of human GABA receptor rho1 subunits contains signals for homooligomeric and heterooligomeric interaction.". J. Biol. Chem. 272 (21): 13750–7. doi:10.1074/jbc.272.21.13750. PMID 9153229.  
  • Kusama T, Hatama K, Sakurai M, et al. (1999). "Consensus phosphorylation sites of human GABA(c)/GABArho receptors are not critical for inhibition by protein kinase C activation.". Neurosci. Lett. 255 (1): 17–20. doi:10.1016/S0304-3940(98)00696-X. PMID 9839716.  
  • Hanley JG, Koulen P, Bedford F, et al. (1999). "The protein MAP-1B links GABA(C) receptors to the cytoskeleton at retinal synapses.". Nature 397 (6714): 66–9. doi:10.1038/16258. PMID 9892354.  
  • Bailey ME, Albrecht BE, Johnson KJ, Darlison MG (1999). "Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3.". Biochim. Biophys. Acta 1447 (2-3): 307–12. PMID 10542332.  
  • Hanley JG, Jones EM, Moss SJ (2000). "GABA receptor rho1 subunit interacts with a novel splice variant of the glycine transporter, GLYT-1.". J. Biol. Chem. 275 (2): 840–6. doi:10.1074/jbc.275.2.840. PMID 10625616.  
  • Filippova N, Sedelnikova A, Zong Y, et al. (2000). "Regulation of recombinant gamma-aminobutyric acid (GABA)(A) and GABA(C) receptors by protein kinase C.". Mol. Pharmacol. 57 (5): 847–56. PMID 10779366.  
  • Billups D, Hanley JG, Orme M, et al. (2001). "GABAC receptor sensitivity is modulated by interaction with MAP1B.". J. Neurosci. 20 (23): 8643–50. PMID 11102469.  
  • Wang QW, Li ZW, Wang F, Yang JQ (2002). "Modulation by divalent cations of GABA rho 1 receptor from human retina expressed in Xenopus oocytes.". Biomed. Environ. Sci. 14 (4): 269–77. PMID 11862606.  
  • Sedelnikova A, Weiss DS (2002). "Phosphorylation of the recombinant rho1 GABA receptor.". Int. J. Dev. Neurosci. 20 (3-5): 237–46. doi:10.1016/S0736-5748(02)00037-0. PMID 12175859.  
  • Torres VI, Weiss DS (2003). "Identification of a tyrosine in the agonist binding site of the homomeric rho1 gamma-aminobutyric acid (GABA) receptor that, when mutated, produces spontaneous opening.". J. Biol. Chem. 277 (46): 43741–8. doi:10.1074/jbc.M202007200. PMID 12226075.  
  • Croci C, Brändstatter JH, Enz R (2003). "ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2.". J. Biol. Chem. 278 (8): 6128–35. doi:10.1074/jbc.M205162200. PMID 12431995.  
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.  
  • Boué-Grabot E, Emerit MB, Toulmé E, et al. (2004). "Cross-talk and co-trafficking between rho1/GABA receptors and ATP-gated channels.". J. Biol. Chem. 279 (8): 6967–75. doi:10.1074/jbc.M307772200. PMID 14660627.  
  • Martínez-Torres A, Miledi R (2004). "A single amino acid change within the ion-channel domain of the gamma-aminobutyric acid rho1 receptor accelerates desensitization and increases taurine agonism.". Arch. Med. Res. 35 (3): 194–8. doi:10.1016/j.arcmed.2003.12.002. PMID 15163459.  
  • Sedelnikova A, Smith CD, Zakharkin SO, et al. (2005). "Mapping the rho1 GABA(C) receptor agonist binding pocket. Constructing a complete model.". J. Biol. Chem. 280 (2): 1535–42. doi:10.1074/jbc.M409908200. PMID 15548535.  
  • Song XQ, Meng F, Ramsey DJ, et al. (2006). "The GABA rho1 subunit interacts with a cellular retinoic acid binding protein in mammalian retina.". Neuroscience 136 (2): 467–75. doi:10.1016/j.neuroscience.2005.08.018. PMID 16198491.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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