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GATA binding protein 3
Identifiers
Symbols GATA3; HDR; MGC2346; MGC5199; MGC5445
External IDs OMIM131320 MGI95663 HomoloGene1550 GeneCards: GATA3 Gene
RNA expression pattern
PBB GE GATA3 209604 s at tn.png
PBB GE GATA3 209602 s at tn.png
PBB GE GATA3 209603 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2625 14462
Ensembl ENSG00000107485 ENSMUSG00000015619
UniProt P23771 Q3TZD6
RefSeq (mRNA) NM_001002295 NM_008091
RefSeq (protein) NP_001002295 NP_032117
Location (UCSC) Chr 10:
8.14 - 8.16 Mb
Chr 2:
9.77 - 9.8 Mb
PubMed search [1] [2]

Trans-acting T-cell-specific transcription factor GATA-3 is a protein that in humans is encoded by the GATA3 gene.[1][2][3]

GATA-3 belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T cell development and plays an important role in endothelial cell biology. GATA-3 has been shown to promote the secretion of IL-4, IL-5, and IL-13 from Th2 cells.

Contents

Clinical significance

Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia.

Interactions

GATA3 has been shown to interact with LMO1.[4][5]

See also

References

  1. ^ Joulin V, Bories D, Eleouet JF, Labastie MC, Chretien S, Mattei MG, Romeo PH (Jul 1991). "A T-cell specific TCR delta DNA binding protein is a member of the human GATA family". EMBO J 10 (7): 1809–16. PMID 2050118.  
  2. ^ Yamashita M, Ukai-Tadenuma M, Miyamoto T, Sugaya K, Hosokawa H, Hasegawa A, Kimura M, Taniguchi M, DeGregori J, Nakayama T (Jun 2004). "Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci". J Biol Chem 279 (26): 26983–90. doi:10.1074/jbc.M403688200. PMID 15087456.  
  3. ^ "Entrez Gene: GATA3 GATA binding protein 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2625.  
  4. ^ Ono, Y; Fukuhara N, Yoshie O (Dec. 1998). "TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3". Mol. Cell. Biol. (UNITED STATES) 18 (12): 6939–50. ISSN 0270-7306. PMID 9819382.  
  5. ^ Ono, Y; Fukuhara N, Yoshie O (Feb. 1997). "Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL". J. Biol. Chem. (UNITED STATES) 272 (7): 4576–81. ISSN 0021-9258. PMID 9020185.  

Further reading

  • Naylor MJ, Ormandy CJ (2007). "Gata-3 and mammary cell fate.". Breast Cancer Res. 9 (2): 302. doi:10.1186/bcr1661. PMID 17381824.  
  • Ho IC, Vorhees P, Marin N, et al. (1991). "Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene.". Embo J. 10 (5): 1187–92. PMID 1827068.  
  • Marine J, Winoto A (1991). "The human enhancer-binding protein Gata3 binds to several T-cell receptor regulatory elements.". Proc. Natl. Acad. Sci. U.S.A. 88 (16): 7284–8. doi:10.1073/pnas.88.16.7284. PMID 1871134.  
  • Ko LJ, Yamamoto M, Leonard MW, et al. (1991). "Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer.". Mol. Cell. Biol. 11 (5): 2778–84. PMID 2017177.  
  • Siegel MD, Zhang DH, Ray P, Ray A (1995). "Activation of the interleukin-5 promoter by cAMP in murine EL-4 cells requires the GATA-3 and CLE0 elements.". J. Biol. Chem. 270 (41): 24548–55. doi:10.1074/jbc.270.41.24548. PMID 7592673.  
  • Labastie MC, Bories D, Chabret C, et al. (1994). "Structure and expression of the human GATA3 gene.". Genomics 21 (1): 1–6. doi:10.1006/geno.1994.1217. PMID 8088776.  
  • Ono Y, Fukuhara N, Yoshie O (1997). "Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL.". J. Biol. Chem. 272 (7): 4576–81. doi:10.1074/jbc.272.7.4576. PMID 9020185.  
  • Ono Y, Fukuhara N, Yoshie O (1998). "TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3.". Mol. Cell. Biol. 18 (12): 6939–50. PMID 9819382.  
  • Yang GP, Ross DT, Kuang WW, et al. (1999). "Combining SSH and cDNA microarrays for rapid identification of differentially expressed genes.". Nucleic Acids Res. 27 (6): 1517–23. doi:10.1093/nar/27.6.1517. PMID 10037815.  
  • Blumenthal SG, Aichele G, Wirth T, et al. (1999). "Regulation of the human interleukin-5 promoter by Ets transcription factors. Ets1 and Ets2, but not Elf-1, cooperate with GATA3 and HTLV-I Tax1.". J. Biol. Chem. 274 (18): 12910–6. doi:10.1074/jbc.274.18.12910. PMID 10212281.  
  • Van Esch H, Groenen P, Nesbit MA, et al. (2000). "GATA3 haplo-insufficiency causes human HDR syndrome.". Nature 406 (6794): 419–22. doi:10.1038/35019088. PMID 10935639.  
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMID 11076863.  
  • Muroya K, Hasegawa T, Ito Y, et al. (2001). "GATA3 abnormalities and the phenotypic spectrum of HDR syndrome.". J. Med. Genet. 38 (6): 374–80. doi:10.1136/jmg.38.6.374. PMID 11389161.  
  • Crawford SE, Qi C, Misra P, et al. (2002). "Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors.". J. Biol. Chem. 277 (5): 3585–92. doi:10.1074/jbc.M107995200. PMID 11724781.  
  • Kieffer LJ, Greally JM, Landres I, et al. (2002). "Identification of a candidate regulatory region in the human CD8 gene complex by colocalization of DNase I hypersensitive sites and matrix attachment regions which bind SATB1 and GATA-3.". J. Immunol. 168 (8): 3915–22. PMID 11937547.  
  • Asnagli H, Afkarian M, Murphy KM (2002). "Cutting edge: Identification of an alternative GATA-3 promoter directing tissue-specific gene expression in mouse and human.". J. Immunol. 168 (9): 4268–71. PMID 11970965.  
  • Steenbergen RD, OudeEngberink VE, Kramer D, et al. (2002). "Down-regulation of GATA-3 expression during human papillomavirus-mediated immortalization and cervical carcinogenesis.". Am. J. Pathol. 160 (6): 1945–51. PMID 12057898.  
  • Höfer T, Nathansen H, Löhning M, et al. (2002). "GATA-3 transcriptional imprinting in Th2 lymphocytes: a mathematical model.". Proc. Natl. Acad. Sci. U.S.A. 99 (14): 9364–8. doi:10.1073/pnas.142284699. PMID 12087127.  
  • Karunaratne A, Hargrave M, Poh A, Yamada T (2002). "GATA proteins identify a novel ventral interneuron subclass in the developing chick spinal cord.". Dev. Biol. 249 (1): 30–43. doi:10.1006/dbio.2002.0754. PMID 12217316.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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