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GATA binding protein 5
Symbols GATA5; bB379O24.1
External IDs MGI109497 HomoloGene32031 GeneCards: GATA5 Gene
Species Human Mouse
Entrez 140628 14464
Ensembl ENSG00000130700 ENSMUSG00000015627
UniProt Q9BWX5 Q0VGI9
RefSeq (mRNA) NM_080473 NM_008093
RefSeq (protein) NP_536721 NP_032119
Location (UCSC) Chr 20:
60.47 - 60.48 Mb
Chr 2:
180.25 - 180.26 Mb
PubMed search [1] [2]

Transcription factor GATA-5 is a protein that in humans is encoded by the GATA5 gene.[1][2]

The protein encoded by this gene is a transcription factor that contains two GATA-type zinc fingers. The encoded protein is known to bind to hepatocyte nuclear factor-1alpha (HNF-1alpha), and this interaction is essential for cooperative activation of the intestinal lactase-phlorizin hydrolase promoter. In other organisms, similar proteins may be involved in the establishment of cardiac smooth muscle cell diversity.[2]


See also


Further reading

  • Kakita T, Hasegawa K, Morimoto T, et al. (1999). "p300 protein as a coactivator of GATA-5 in the transcription of cardiac-restricted atrial natriuretic factor gene.". J. Biol. Chem. 274 (48): 34096–102. doi:10.1074/jbc.274.48.34096. PMID 10567378.  
  • Krasinski SD, Van Wering HM, Tannemaat MR, Grand RJ (2001). "Differential activation of intestinal gene promoters: functional interactions between GATA-5 and HNF-1 alpha.". Am. J. Physiol. Gastrointest. Liver Physiol. 281 (1): G69–84. PMID 11408257.  
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.  
  • van Wering HM, Huibregtse IL, van der Zwan SM, et al. (2002). "Physical interaction between GATA-5 and hepatocyte nuclear factor-1alpha results in synergistic activation of the human lactase-phlorizin hydrolase promoter.". J. Biol. Chem. 277 (31): 27659–67. doi:10.1074/jbc.M203645200. PMID 12011060.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Benchabane H, Wrana JL (2003). "GATA- and Smad1-dependent enhancers in the Smad7 gene differentially interpret bone morphogenetic protein concentrations.". Mol. Cell. Biol. 23 (18): 6646–61. doi:10.1128/MCB.23.18.6646-6661.2003. PMID 12944489.  
  • Akiyama Y, Watkins N, Suzuki H, et al. (2003). "GATA-4 and GATA-5 transcription factor genes and potential downstream antitumor target genes are epigenetically silenced in colorectal and gastric cancer.". Mol. Cell. Biol. 23 (23): 8429–39. doi:10.1128/MCB.23.23.8429-8439.2003. PMID 14612389.  
  • Divine JK, Staloch LJ, Haveri H, et al. (2004). "GATA-4, GATA-5, and GATA-6 activate the rat liver fatty acid binding protein gene in concert with HNF-1alpha.". Am. J. Physiol. Gastrointest. Liver Physiol. 287 (5): G1086–99. doi:10.1152/ajpgi.00421.2003. PMID 14715527.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Guo M, Akiyama Y, House MG, et al. (2005). "Hypermethylation of the GATA genes in lung cancer.". Clin. Cancer Res. 10 (23): 7917–24. doi:10.1158/1078-0432.CCR-04-1140. PMID 15585625.  
  • Wakana K, Akiyama Y, Aso T, Yuasa Y (2006). "Involvement of GATA-4/-5 transcription factors in ovarian carcinogenesis.". Cancer Lett. 241 (2): 281–8. doi:10.1016/j.canlet.2005.10.039. PMID 16337738.  
  • Guo M, House MG, Akiyama Y, et al. (2006). "Hypermethylation of the GATA gene family in esophageal cancer.". Int. J. Cancer 119 (9): 2078–83. doi:10.1002/ijc.22092. PMID 16823849.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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