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Gastrulation brain homeobox 2
Identifiers
Symbols GBX2;
External IDs OMIM601135 MGI95668 HomoloGene1138 GeneCards: GBX2 Gene
RNA expression pattern
PBB GE GBX2 210560 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2637 14472
Ensembl ENSG00000168505 ENSMUSG00000034486
UniProt P52951 Q14A66
RefSeq (mRNA) NM_001485 NM_010262
RefSeq (protein) NP_001476 NP_034392
Location (UCSC) Chr 2:
236.74 - 236.74 Mb
Chr 1:
91.76 - 91.76 Mb
PubMed search [1] [2]

Homeobox protein GBX-2 is a protein that in humans is encoded by the GBX2 gene.[1][2][3]

References

  1. ^ Kowenz-Leutz E, Herr P, Niss K, Leutz A (Nov 1997). "The homeobox gene GBX2, a target of the myb oncogene, mediates autocrine growth and monocyte differentiation". Cell 91 (2): 185-95. PMID 9346236.  
  2. ^ Lin X, Swaroop A, Vaccarino FM, Murtha MT, Haas M, Ji X, Ruddle FH, Leckman JF (Mar 1997). "Characterization and sequence analysis of the human homeobox-containing gene GBX2". Genomics 31 (3): 335-42. doi:10.1006/geno.1996.0056. PMID 8838315.  
  3. ^ "Entrez Gene: GBX2 gastrulation brain homeobox 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2637.  

Further reading

  • Heimbucher T, Murko C, Bajoghli B, et al. (2007). "Gbx2 and Otx2 interact with the WD40 domain of Groucho/Tle corepressors.". Mol. Cell. Biol. 27 (1): 340–51. doi:10.1128/MCB.00811-06. PMID 17060451.  
  • Glinsky GV, Berezovska O, Glinskii AB (2005). "Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer.". J. Clin. Invest. 115 (6): 1503–21. doi:10.1172/JCI23412. PMID 15931389.  
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.  
  • Gao AC, Lou W, Isaacs JT (2000). "Enhanced GBX2 expression stimulates growth of human prostate cancer cells via transcriptional up-regulation of the interleukin 6 gene.". Clin. Cancer Res. 6 (2): 493–7. PMID 10690529.  
  • Gao AC, Lou W, Isaacs JT (1998). "Down-regulation of homeobox gene GBX2 expression inhibits human prostate cancer clonogenic ability and tumorigenicity.". Cancer Res. 58 (7): 1391–4. PMID 9537237.  
  • Matsui T, Hirai M, Hirano M, Kurosawa Y (1994). "The HOX complex neighbored by the EVX gene, as well as two other homeobox-containing genes, the GBX-class and the EN-class, are located on the same chromosomes 2 and 7 in humans.". FEBS Lett. 336 (1): 107–10. PMID 7903253.  
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