The Full Wiki

GFI1: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

edit
Growth factor independent 1
Identifiers
Symbols GFI1; ZNF163
External IDs OMIM600871 MGI103170 HomoloGene3854 GeneCards: GFI1 Gene
RNA expression pattern
PBB GE GFI1 206589 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2672 14581
Ensembl ENSG00000162676 ENSMUSG00000029275
UniProt Q99684 P70338
RefSeq (mRNA) NM_005263 NM_010278
RefSeq (protein) NP_005254 NP_034408
Location (UCSC) Chr 1:
92.71 - 92.73 Mb
Chr 5:
107.96 - 107.97 Mb
PubMed search [1] [2]

Zinc finger protein Gfi-1 is a protein that in humans is encoded by the GFI1 gene.[1][2]

Contents

Interactions

GFI1 has been shown to interact with PIAS3[3] and RUNX1T1.[4]

References

  1. ^ Bell DW, Taguchi T, Jenkins NA, Gilbert DJ, Copeland NG, Gilks CB, Zweidler-McKay P, Grimes HL, Tsichlis PN, Testa JR (Jul 1995). "Chromosomal localization of a gene, GF1, encoding a novel zinc finger protein reveals a new syntenic region between man and rodents". Cytogenet Cell Genet 70 (3-4): 263–7. PMID 7789186.  
  2. ^ "Entrez Gene: GFI1 growth factor independent 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2672.  
  3. ^ Rödel, B; Tavassoli K, Karsunky H, Schmidt T, Bachmann M, Schaper F, Heinrich P, Shuai K, Elsässer H P, Möröy T (Nov. 2000). "The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3". EMBO J. (ENGLAND) 19 (21): 5845–55. doi:10.1093/emboj/19.21.5845. ISSN 0261-4189. PMID 11060035.  
  4. ^ McGhee, Laura; Bryan Josh, Elliott Liza, Grimes H Leighton, Kazanjian Avedis, Davis J Nathan, Meyers Shari (Aug. 2003). "Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism". J. Cell. Biochem. (United States) 89 (5): 1005–18. doi:10.1002/jcb.10548. ISSN 0730-2312. PMID 12874834.  

Further reading

  • Gilks CB, Bear SE, Grimes HL, Tsichlis PN (1993). "Progression of interleukin-2 (IL-2)-dependent rat T cell lymphoma lines to IL-2-independent growth following activation of a gene (Gfi-1) encoding a novel zinc finger protein.". Mol. Cell. Biol. 13 (3): 1759–68. PMID 8441411.  
  • Zweidler-Mckay PA, Grimes HL, Flubacher MM, Tsichlis PN (1996). "Gfi-1 encodes a nuclear zinc finger protein that binds DNA and functions as a transcriptional repressor.". Mol. Cell. Biol. 16 (8): 4024–34. PMID 8754800.  
  • Roberts T, Cowell JK (1997). "Cloning of the human Gfi-1 gene and its mapping to chromosome region 1p22.". Oncogene 14 (8): 1003–5. doi:10.1038/sj.onc.1200910. PMID 9051000.  
  • Rödel B, Tavassoli K, Karsunky H, et al. (2000). "The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3.". EMBO J. 19 (21): 5845–55. doi:10.1093/emboj/19.21.5845. PMID 11060035.  
  • Osawa M, Yamaguchi T, Nakamura Y, et al. (2002). "Erythroid expansion mediated by the Gfi-1B zinc finger protein: role in normal hematopoiesis.". Blood 100 (8): 2769–77. doi:10.1182/blood-2002-01-0182. PMID 12351384.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Person RE, Li FQ, Duan Z, et al. (2003). "Mutations in proto-oncogene GFI1 cause human neutropenia and target ELA2.". Nat. Genet. 34 (3): 308–12. doi:10.1038/ng1170. PMID 12778173.  
  • McGhee L, Bryan J, Elliott L, et al. (2003). "Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism.". J. Cell. Biochem. 89 (5): 1005–18. doi:10.1002/jcb.10548. PMID 12874834.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Doan LL, Porter SD, Duan Z, et al. (2004). "Targeted transcriptional repression of Gfi1 by GFI1 and GFI1B in lymphoid cells.". Nucleic Acids Res. 32 (8): 2508–19. doi:10.1093/nar/gkh570. PMID 15131254.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Dwivedi PP, Anderson PH, Omdahl JL, et al. (2005). "Identification of growth factor independent-1 (GFI1) as a repressor of 25-hydroxyvitamin D 1-alpha hydroxylase (CYP27B1) gene expression in human prostate cancer cells.". Endocr. Relat. Cancer 12 (2): 351–65. doi:10.1677/erc.1.00920. PMID 15947108.  
  • Duan Z, Zarebski A, Montoya-Durango D, et al. (2005). "Gfi1 coordinates epigenetic repression of p21Cip/WAF1 by recruitment of histone lysine methyltransferase G9a and histone deacetylase 1.". Mol. Cell. Biol. 25 (23): 10338–51. doi:10.1128/MCB.25.23.10338-10351.2005. PMID 16287849.  
  • Marteijn JA, van der Meer LT, Van Emst L, et al. (2007). "Diminished proteasomal degradation results in accumulation of Gfi1 protein in monocytes.". Blood 109 (1): 100–8. doi:10.1182/blood-2006-02-003590. PMID 16888099.  
  • Dwivedi PP, Anderson PH, Tilley WD, et al. (2007). "Role of oncoprotein growth factor independent-1 (GFI1) in repression of 25-hydroxyvitamin D 1alpha-hydroxylase (CYP27B1): a comparative analysis in human prostate cancer and kidney cells.". J. Steroid Biochem. Mol. Biol. 103 (3-5): 742–6. doi:10.1016/j.jsbmb.2006.12.014. PMID 17207994.  
  • Nakazawa Y, Suzuki M, Manabe N, et al. (2007). "Cooperative interaction between ETS1 and GFI1 transcription factors in the repression of Bax gene expression.". Oncogene 26 (24): 3541–50. doi:10.1038/sj.onc.1210140. PMID 17213822.  
  • Khanna-Gupta A, Sun H, Zibello T, et al. (2007). "Growth factor independence-1 (Gfi-1) plays a role in mediating specific granule deficiency (SGD) in a patient lacking a gene-inactivating mutation in the C/EBPepsilon gene.". Blood 109 (10): 4181–90. doi:10.1182/blood-2005-05-022004. PMID 17244686.  
  • Marteijn JA, van der Meer LT, van Emst L, et al. (2007). "Gfi1 ubiquitination and proteasomal degradation is inhibited by the ubiquitin ligase Triad1.". Blood 110 (9): 3128–35. doi:10.1182/blood-2006-11-058602. PMID 17646546.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message