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GFI1: Wikis


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Growth factor independent 1
Symbols GFI1; ZNF163
External IDs OMIM600871 MGI103170 HomoloGene3854 GeneCards: GFI1 Gene
RNA expression pattern
PBB GE GFI1 206589 at tn.png
More reference expression data
Species Human Mouse
Entrez 2672 14581
Ensembl ENSG00000162676 ENSMUSG00000029275
UniProt Q99684 P70338
RefSeq (mRNA) NM_005263 NM_010278
RefSeq (protein) NP_005254 NP_034408
Location (UCSC) Chr 1:
92.71 - 92.73 Mb
Chr 5:
107.96 - 107.97 Mb
PubMed search [1] [2]

Zinc finger protein Gfi-1 is a protein that in humans is encoded by the GFI1 gene.[1][2]



GFI1 has been shown to interact with PIAS3[3] and RUNX1T1.[4]


  1. ^ Bell DW, Taguchi T, Jenkins NA, Gilbert DJ, Copeland NG, Gilks CB, Zweidler-McKay P, Grimes HL, Tsichlis PN, Testa JR (Jul 1995). "Chromosomal localization of a gene, GF1, encoding a novel zinc finger protein reveals a new syntenic region between man and rodents". Cytogenet Cell Genet 70 (3-4): 263–7. PMID 7789186.  
  2. ^ "Entrez Gene: GFI1 growth factor independent 1".  
  3. ^ Rödel, B; Tavassoli K, Karsunky H, Schmidt T, Bachmann M, Schaper F, Heinrich P, Shuai K, Elsässer H P, Möröy T (Nov. 2000). "The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3". EMBO J. (ENGLAND) 19 (21): 5845–55. doi:10.1093/emboj/19.21.5845. ISSN 0261-4189. PMID 11060035.  
  4. ^ McGhee, Laura; Bryan Josh, Elliott Liza, Grimes H Leighton, Kazanjian Avedis, Davis J Nathan, Meyers Shari (Aug. 2003). "Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism". J. Cell. Biochem. (United States) 89 (5): 1005–18. doi:10.1002/jcb.10548. ISSN 0730-2312. PMID 12874834.  

Further reading

  • Gilks CB, Bear SE, Grimes HL, Tsichlis PN (1993). "Progression of interleukin-2 (IL-2)-dependent rat T cell lymphoma lines to IL-2-independent growth following activation of a gene (Gfi-1) encoding a novel zinc finger protein.". Mol. Cell. Biol. 13 (3): 1759–68. PMID 8441411.  
  • Zweidler-Mckay PA, Grimes HL, Flubacher MM, Tsichlis PN (1996). "Gfi-1 encodes a nuclear zinc finger protein that binds DNA and functions as a transcriptional repressor.". Mol. Cell. Biol. 16 (8): 4024–34. PMID 8754800.  
  • Roberts T, Cowell JK (1997). "Cloning of the human Gfi-1 gene and its mapping to chromosome region 1p22.". Oncogene 14 (8): 1003–5. doi:10.1038/sj.onc.1200910. PMID 9051000.  
  • Rödel B, Tavassoli K, Karsunky H, et al. (2000). "The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3.". EMBO J. 19 (21): 5845–55. doi:10.1093/emboj/19.21.5845. PMID 11060035.  
  • Osawa M, Yamaguchi T, Nakamura Y, et al. (2002). "Erythroid expansion mediated by the Gfi-1B zinc finger protein: role in normal hematopoiesis.". Blood 100 (8): 2769–77. doi:10.1182/blood-2002-01-0182. PMID 12351384.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Person RE, Li FQ, Duan Z, et al. (2003). "Mutations in proto-oncogene GFI1 cause human neutropenia and target ELA2.". Nat. Genet. 34 (3): 308–12. doi:10.1038/ng1170. PMID 12778173.  
  • McGhee L, Bryan J, Elliott L, et al. (2003). "Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism.". J. Cell. Biochem. 89 (5): 1005–18. doi:10.1002/jcb.10548. PMID 12874834.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Doan LL, Porter SD, Duan Z, et al. (2004). "Targeted transcriptional repression of Gfi1 by GFI1 and GFI1B in lymphoid cells.". Nucleic Acids Res. 32 (8): 2508–19. doi:10.1093/nar/gkh570. PMID 15131254.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Dwivedi PP, Anderson PH, Omdahl JL, et al. (2005). "Identification of growth factor independent-1 (GFI1) as a repressor of 25-hydroxyvitamin D 1-alpha hydroxylase (CYP27B1) gene expression in human prostate cancer cells.". Endocr. Relat. Cancer 12 (2): 351–65. doi:10.1677/erc.1.00920. PMID 15947108.  
  • Duan Z, Zarebski A, Montoya-Durango D, et al. (2005). "Gfi1 coordinates epigenetic repression of p21Cip/WAF1 by recruitment of histone lysine methyltransferase G9a and histone deacetylase 1.". Mol. Cell. Biol. 25 (23): 10338–51. doi:10.1128/MCB.25.23.10338-10351.2005. PMID 16287849.  
  • Marteijn JA, van der Meer LT, Van Emst L, et al. (2007). "Diminished proteasomal degradation results in accumulation of Gfi1 protein in monocytes.". Blood 109 (1): 100–8. doi:10.1182/blood-2006-02-003590. PMID 16888099.  
  • Dwivedi PP, Anderson PH, Tilley WD, et al. (2007). "Role of oncoprotein growth factor independent-1 (GFI1) in repression of 25-hydroxyvitamin D 1alpha-hydroxylase (CYP27B1): a comparative analysis in human prostate cancer and kidney cells.". J. Steroid Biochem. Mol. Biol. 103 (3-5): 742–6. doi:10.1016/j.jsbmb.2006.12.014. PMID 17207994.  
  • Nakazawa Y, Suzuki M, Manabe N, et al. (2007). "Cooperative interaction between ETS1 and GFI1 transcription factors in the repression of Bax gene expression.". Oncogene 26 (24): 3541–50. doi:10.1038/sj.onc.1210140. PMID 17213822.  
  • Khanna-Gupta A, Sun H, Zibello T, et al. (2007). "Growth factor independence-1 (Gfi-1) plays a role in mediating specific granule deficiency (SGD) in a patient lacking a gene-inactivating mutation in the C/EBPepsilon gene.". Blood 109 (10): 4181–90. doi:10.1182/blood-2005-05-022004. PMID 17244686.  
  • Marteijn JA, van der Meer LT, van Emst L, et al. (2007). "Gfi1 ubiquitination and proteasomal degradation is inhibited by the ubiquitin ligase Triad1.". Blood 110 (9): 3128–35. doi:10.1182/blood-2006-11-058602. PMID 17646546.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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