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glycine receptor, alpha 3
Symbol GLRA3
External IDs OMIM600421 MGI95749 HomoloGene142 IUPHAR: α3 GeneCards: GLRA3 Gene
Species Human Mouse
Entrez 8001 110304
Ensembl ENSG00000145451 ENSMUSG00000038257
UniProt O75311 Q91XP5
RefSeq (mRNA) NM_006529 NM_080438
RefSeq (protein) NP_006520 NP_536686
Location (UCSC) Chr 4:
175.8 - 175.99 Mb
Chr 8:
58.42 - 58.6 Mb
PubMed search [1] [2]

The Glycine receptor subunit alpha-3 is a protein that in humans is encoded by the GLRA3 gene.[1] The protein encoded by this gene is a subunit of the glycine receptor.[1]

Variants of this receptor subunit is associated with susceptibility to epilepsy.[2]


  1. ^ a b Nikolic Z, Laube B, Weber RG, Lichter P, Kioschis P, Poustka A, Mulhardt C, Becker CM (Sep 1998). "The human glycine receptor subunit alpha3. Glra3 gene structure, chromosomal localization, and functional characterization of alternative transcripts". J Biol Chem 273 (31): 19708-14. PMID 9677400.  
  2. ^ Sobetzko D, Sander T, Becker CM (August 2001). "Genetic variation of the human glycine receptor subunit genes GLRA3 and GLRB and susceptibility to idiopathic generalized epilepsies". Am. J. Med. Genet. 105 (6): 534–8. doi:10.1002/ajmg.1488. PMID 11496371.  

Further reading

  • Breitinger HG, Villmann C, Rennert J, et al. (2002). "Hydroxylated residues influence desensitization behaviour of recombinant alpha3 glycine receptor channels.". J. Neurochem. 83 (1): 30-6. PMID 12358726.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.  
  • Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491-6. PMID 10737800.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Gratacòs M, Costas J, de Cid R, et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808-16. doi:10.1002/ajmg.b.30902. PMID 19086053.  

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