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solute carrier family 2 (facilitated glucose/fructose transporter), member 5
Identifiers
Symbol SLC2A5
Alt. symbols GLUT5
Entrez 6518
HUGO 11010
OMIM 138230
RefSeq NM_003039
UniProt P22732
Other data
Locus Chr. 1 p36.2

GLUT5 is a fructose transporter expressed on the apical border of enterocytes in the small intestine.[1] GLUT5 allows for fructose to be transported from the intestinal lumen into the enterocyte by facilitated diffusion due to fructose's high concentration in the intestinal lumen. GLUT5 is also expressed in skeletal muscle,[2] testis, kidney, fat tissue, and brain.[3]

Fructose malabsorption or Dietary Fructose Intolerance is a dietary disability of the small intestine, where the amount of fructose carrier in enterocytes is deficient.[4]

In humans the GLUT5 protein is encoded by the SLC2A5 gene.[5]

References

  1. ^ Uldry M, Thorens B (February 2004). "The SLC2 family of facilitated hexose and polyol transporters". Pflügers Archiv : European Journal of Physiology 447 (5): 480–9. doi:10.1007/s00424-003-1085-0. PMID 12750891.  
  2. ^ Hundal HS, Darakhshan F, Kristiansen S, Blakemore SJ, Richter EA (1998). "GLUT5 expression and fructose transport in human skeletal muscle". Advances in Experimental Medicine and Biology 441: 35–45. PMID 9781312.  
  3. ^ Douard V, Ferraris RP (August 2008). "Regulation of the fructose transporter GLUT5 in health and disease". American Journal of Physiology. Endocrinology and Metabolism 295 (2): E227–37. doi:10.1152/ajpendo.90245.2008. PMID 18398011.  
  4. ^ Barone S, Fussell SL, Singh AK, Lucas F, Xu J, Kim C, Wu X, Yu Y, Amlal H, Seidler U, Zuo J, Soleimani M (February 2009). "Slc2a5 (Glut5) is essential for the absorption of fructose in the intestine and generation of fructose-induced hypertension". The Journal of Biological Chemistry 284 (8): 5056–66. doi:10.1074/jbc.M808128200. PMID 19091748.  
  5. ^ White PS, Jensen SJ, Rajalingam V, Stairs D, Sulman EP, Maris JM, Biegel JA, Wooster R, Brodeur GM (1998). "Physical mapping of the CA6, ENO1, and SLC2A5 (GLUT5) genes and reassignment of SLC2A5 to 1p36.2". Cytogenetics and Cell Genetics 81 (1): 60–4. doi:10.1159/000014989. PMID 9691177.  

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