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Guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
Symbols GNA11; GNA-11
External IDs OMIM139313 MGI95766 HomoloGene20474 GeneCards: GNA11 Gene
RNA expression pattern
PBB GE GNA11 564 at tn.png
PBB GE GNA11 40562 at tn.png
PBB GE GNA11 204248 at tn.png
More reference expression data
Species Human Mouse
Entrez 2767 14672
Ensembl ENSG00000088256 ENSMUSG00000034781
UniProt P29992 Q3UPA1
RefSeq (mRNA) NM_002067 NM_010301
RefSeq (protein) NP_002058 NP_034431
Location (UCSC) Chr 19:
3.05 - 3.07 Mb
Chr 10:
80.93 - 80.95 Mb
PubMed search [1] [2]

Guanine nucleotide-binding protein subunit alpha-11 is a protein that in humans is encoded by the GNA11 gene.[1][2]

See also


  1. ^ Wilkie TM, Gilbert DJ, Olsen AS, Chen XN, Amatruda TT, Korenberg JR, Trask BJ, de Jong P, Reed RR, Simon MI, et al. (Jun 1993). "Evolution of the mammalian G protein alpha subunit multigene family". Nat Genet 1 (2): 85-91. doi:10.1038/ng0592-85. PMID 1302014.  
  2. ^ "Entrez Gene: GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)".  

Further reading

  • Raymond JR, Mukhin YV, Gelasco A, et al. (2002). "Multiplicity of mechanisms of serotonin receptor signal transduction.". Pharmacol. Ther. 92 (2-3): 179–212. doi:10.1016/S0163-7258(01)00169-3. PMID 11916537.  
  • Jiang M, Pandey S, Tran VT, Fong HK (1991). "Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells.". Proc. Natl. Acad. Sci. U.S.A. 88 (9): 3907–11. doi:10.1073/pnas.88.9.3907. PMID 1902575.  
  • Thomas CP, Dunn MJ, Mattera R (1996). "Ca2+ signalling in K562 human erythroleukaemia cells: effect of dimethyl sulphoxide and role of G-proteins in thrombin- and thromboxane A2-activated pathways.". Biochem. J. 312 ( Pt 1): 151–8. PMID 7492305.  
  • Offermanns S, Simon MI (1995). "G alpha 15 and G alpha 16 couple a wide variety of receptors to phospholipase C.". J. Biol. Chem. 270 (25): 15175–80. doi:10.1074/jbc.270.25.15175. PMID 7797501.  
  • Stanners J, Kabouridis PS, McGuire KL, Tsoukas CD (1996). "Interaction between G proteins and tyrosine kinases upon T cell receptor.CD3-mediated signaling.". J. Biol. Chem. 270 (51): 30635–42. doi:10.1074/jbc.270.51.30635. PMID 8530500.  
  • Laugwitz KL, Allgeier A, Offermanns S, et al. (1996). "The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families.". Proc. Natl. Acad. Sci. U.S.A. 93 (1): 116–20. doi:10.1073/pnas.93.1.116. PMID 8552586.  
  • Launay JM, Birraux G, Bondoux D, et al. (1996). "Ras involvement in signal transduction by the serotonin 5-HT2B receptor.". J. Biol. Chem. 271 (6): 3141–7. doi:10.1074/jbc.271.6.3141. PMID 8621713.  
  • Johnson GJ, Leis LA, Dunlop PC (1996). "Specificity of G alpha q and G alpha 11 gene expression in platelets and erythrocytes. Expressions of cellular differentiation and species differences.". Biochem. J. 318 ( Pt 3): 1023–31. PMID 8836152.  
  • Kinsella BT, O'Mahony DJ, Fitzgerald GA (1997). "The human thromboxane A2 receptor alpha isoform (TP alpha) functionally couples to the G proteins Gq and G11 in vivo and is activated by the isoprostane 8-epi prostaglandin F2 alpha.". J. Pharmacol. Exp. Ther. 281 (2): 957–64. PMID 9152406.  
  • Wise A, Parenti M, Milligan G (1997). "Interaction of the G-protein G11alpha with receptors and phosphoinositidase C: the contribution of G-protein palmitoylation and membrane association.". FEBS Lett. 407 (3): 257–60. doi:10.1016/S0014-5793(97)00300-1. PMID 9175863.  
  • Carrasco MP, Asbóth G, Phaneuf S, López Bernal A (1998). "Activation of the prostaglandin FP receptor in human granulosa cells.". J. Reprod. Fertil. 111 (2): 309–17. PMID 9462300.  
  • Qian A, Wang W, Sanborn BM (1998). "Evidence for the involvement of several intracellular domains in the coupling of oxytocin receptor to G alpha(q/11).". Cell. Signal. 10 (2): 101–5. doi:10.1016/S0898-6568(97)00097-1. PMID 9481484.  
  • Dulin NO, Sorokin A, Reed E, et al. (1999). "RGS3 inhibits G protein-mediated signaling via translocation to the membrane and binding to Galpha11.". Mol. Cell. Biol. 19 (1): 714–23. PMID 9858594.  
  • Hayes JS, Lawler OA, Walsh MT, Kinsella BT (1999). "The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling.". J. Biol. Chem. 274 (34): 23707–18. doi:10.1074/jbc.274.34.23707. PMID 10446129.  
  • Brydon L, Roka F, Petit L, et al. (2000). "Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins.". Mol. Endocrinol. 13 (12): 2025–38. doi:10.1210/me.13.12.2025. PMID 10598579.  
  • Corbetta S, Mantovani G, Lania A, et al. (2000). "Calcium-sensing receptor expression and signalling in human parathyroid adenomas and primary hyperplasia.". Clin. Endocrinol. (Oxf) 52 (3): 339–48. doi:10.1046/j.1365-2265.2000.00933.x. PMID 10718832.  
  • Shraga-Levine Z, Sokolovsky M (2000). "Functional coupling of G proteins to endothelin receptors is ligand and receptor subtype specific.". Cell. Mol. Neurobiol. 20 (3): 305–17. doi:10.1023/A:1007010125316. PMID 10789830.  
  • AbdAlla S, Lother H, Abdel-tawab AM, Quitterer U (2001). "The angiotensin II AT2 receptor is an AT1 receptor antagonist.". J. Biol. Chem. 276 (43): 39721–6. doi:10.1074/jbc.M105253200. PMID 11507095.  


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