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Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1

PDB rendering based on 1fqj.
Available structures
1fqj, 1fqk, 1got, 1tad, 1tag, 1tnd
Identifiers
Symbols GNAT1; GBT1; GNATR
External IDs OMIM139330 MGI95778 HomoloGene20084 GeneCards: GNAT1 Gene
RNA expression pattern
PBB GE GNAT1 214286 at tn.png
PBB GE GNAT1 207514 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2779 14685
Ensembl ENSG00000114349 ENSMUSG00000034837
UniProt P11488 P20612
RefSeq (mRNA) NM_000172 NM_008140
RefSeq (protein) NP_000163 NP_032166
Location (UCSC) Chr 3:
50.2 - 50.21 Mb
Chr 9:
107.53 - 107.54 Mb
PubMed search [1] [2]

Guanine nucleotide-binding protein G(t) subunit alpha-1 is a protein that in humans is encoded by the GNAT1 gene.[1]

Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in rods. Alternative splicing of this gene results in two transcript variants.[1]

References

Further reading

  • Wilkie TM, Gilbert DJ, Olsen AS, et al. (1993). "Evolution of the mammalian G protein alpha subunit multigene family.". Nat. Genet. 1 (2): 85–91. doi:10.1038/ng0592-85. PMID 1302014.  
  • Bourne HR, Sanders DA, McCormick F (1991). "The GTPase superfamily: conserved structure and molecular mechanism.". Nature 349 (6305): 117–27. doi:10.1038/349117a0. PMID 1898771.  
  • Fong SL (1992). "Characterization of the human rod transducin alpha-subunit gene.". Nucleic Acids Res. 20 (11): 2865–70. doi:10.1093/nar/20.11.2865. PMID 1614872.  
  • Lerea CL, Bunt-Milam AH, Hurley JB (1990). "Alpha transducin is present in blue-, green-, and red-sensitive cone photoreceptors in the human retina.". Neuron 3 (3): 367–76. doi:10.1016/0896-6273(89)90261-4. PMID 2534964.  
  • Van Dop C, Medynski DC, Apone LM (1989). "Nucleotide sequence for a cDNA encoding the alpha subunit of retinal transducin (GNAT1) isolated from the human eye.". Nucleic Acids Res. 17 (12): 4887. doi:10.1093/nar/17.12.4887. PMID 2748346.  
  • Blatt C, Eversole-Cire P, Cohn VH, et al. (1988). "Chromosomal localization of genes encoding guanine nucleotide-binding protein subunits in mouse and human.". Proc. Natl. Acad. Sci. U.S.A. 85 (20): 7642–6. doi:10.1073/pnas.85.20.7642. PMID 2902634.  
  • Ngo JT, Bateman JB, Klisak I, et al. (1994). "Regional mapping of a human rod alpha-transducin (GNAT1) gene to chromosome 3p22.". Genomics 18 (3): 724–5. doi:10.1016/S0888-7543(05)80384-2. PMID 8307584.  
  • Dryja TP, Hahn LB, Reboul T, Arnaud B (1996). "Missense mutation in the gene encoding the alpha subunit of rod transducin in the Nougaret form of congenital stationary night blindness.". Nat. Genet. 13 (3): 358–60. doi:10.1038/ng0796-358. PMID 8673138.  
  • Chen CK, Wieland T, Simon MI (1996). "RGS-r, a retinal specific RGS protein, binds an intermediate conformation of transducin and enhances recycling.". Proc. Natl. Acad. Sci. U.S.A. 93 (23): 12885–9. doi:10.1073/pnas.93.23.12885. PMID 8917514.  
  • Seibert C, Harteneck C, Ernst OP, et al. (2000). "Activation of the rod G-protein Gt by the thrombin receptor (PAR1) expressed in Sf9 cells.". Eur. J. Biochem. 266 (3): 911–6. doi:10.1046/j.1432-1327.1999.00927.x. PMID 10583385.  
  • Wieland T, Bahtijari N, Zhou XB, et al. (2000). "Polarity exchange at the interface of regulators of G protein signaling with G protein alpha-subunits.". J. Biol. Chem. 275 (37): 28500–6. doi:10.1074/jbc.M004187200. PMID 10878019.  
  • Bell MW, Desai N, Guo XX, Ghalayini AJ (2000). "Tyrosine phosphorylation of the alpha subunit of transducin and its association with Src in photoreceptor rod outer segments.". J. Neurochem. 75 (5): 2006–19. doi:10.1046/j.1471-4159.2000.0752006.x. PMID 11032890.  
  • Hu G, Wensel TG (2002). "R9AP, a membrane anchor for the photoreceptor GTPase accelerating protein, RGS9-1.". Proc. Natl. Acad. Sci. U.S.A. 99 (15): 9755–60. doi:10.1073/pnas.152094799. PMID 12119397.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Muzny DM, Scherer SE, Kaul R, et al. (2006). "The DNA sequence, annotation and analysis of human chromosome 3.". Nature 440 (7088): 1194–8. doi:10.1038/nature04728. PMID 16641997.  
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