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G protein-coupled receptor 1
Symbols GPR1;
External IDs OMIM600239 MGI2385324 HomoloGene21094 IUPHAR: GPR1 GeneCards: GPR1 Gene
RNA expression pattern
PBB GE GPR1 214605 x at tn.png
More reference expression data
Species Human Mouse
Entrez 2825 241070
Ensembl ENSG00000183671 ENSMUSG00000046856
UniProt P46091 Q8K087
RefSeq (mRNA) NM_005279 NM_146250
RefSeq (protein) NP_005270 NP_666362
Location (UCSC) Chr 2:
206.75 - 206.79 Mb
Chr 1:
63.12 - 63.15 Mb
PubMed search [1] [2]

G protein-coupled receptor 1, also known as GPR1, is an orphan receptor of the G protein-coupled receptor family.[1]


Further reading

  • Marchese A, Docherty JM, Nguyen T, et al. (1995). "Cloning of human genes encoding novel G protein-coupled receptors.". Genomics 23 (3): 609–18. doi:10.1006/geno.1994.1549. PMID 7851889.  
  • Shimizu N, Soda Y, Kanbe K, et al. (1999). "An orphan G protein-coupled receptor, GPR1, acts as a coreceptor to allow replication of human immunodeficiency virus types 1 and 2 in brain-derived cells.". J. Virol. 73 (6): 5231–9. PMID 10233994.  
  • Tokizawa S, Shimizu N, Hui-Yu L, et al. (2000). "Infection of mesangial cells with HIV and SIV: identification of GPR1 as a coreceptor.". Kidney Int. 58 (2): 607–17. doi:10.1046/j.1523-1755.2000.00207.x. PMID 10916084.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Kang MK, Kameta A, Shin KH, et al. (2003). "Senescence-associated genes in normal human oral keratinocytes.". Exp. Cell Res. 287 (2): 272–81. doi:10.1016/S0014-4827(03)00061-2. PMID 12837283.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.  
  • Jinno-Oue A, Shimizu N, Soda Y, et al. (2005). "The synthetic peptide derived from the NH2-terminal extracellular region of an orphan G protein-coupled receptor, GPR1, preferentially inhibits infection of X4 HIV-1.". J. Biol. Chem. 280 (35): 30924–34. doi:10.1074/jbc.M500195200. PMID 15919664.  
  • Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.  
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.  


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