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GPR124: Wikis


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G protein-coupled receptor 124
Symbols GPR124; DKFZp434C211; DKFZp434J0911; FLJ14390; KIAA1531; TEM5
External IDs OMIM606823 MGI1925810 HomoloGene13112 IUPHAR: GPR124 GeneCards: GPR124 Gene
RNA expression pattern
PBB GE GPR124 221814 at tn.png
PBB GE GPR124 65718 at tn.png
More reference expression data
Species Human Mouse
Entrez 25960 78560
Ensembl ENSG00000020181 ENSMUSG00000031486
UniProt Q96PE1 Q91ZV8
RefSeq (mRNA) NM_032777 NM_054044
RefSeq (protein) NP_116166 NP_473385
Location (UCSC) Chr 8:
37.77 - 37.82 Mb
Chr 8:
28.55 - 28.59 Mb
PubMed search [1] [2]

Probable G-protein coupled receptor 124 is a protein that in humans is encoded by the GPR124 gene.[1][2][3]


GPR124 has been shown to interact with DLG1.[4]


  1. ^ Carson-Walter EB, Watkins DN, Nanda A, Vogelstein B, Kinzler KW, St Croix B (Sep 2001). "Cell surface tumor endothelial markers are conserved in mice and humans". Cancer Res 61 (18): 6649–55. PMID 11559528.  
  2. ^ Fredriksson R, Gloriam DE, Hoglund PJ, Lagerstrom MC, Schioth HB (Feb 2003). "There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini". Biochem Biophys Res Commun 301 (3): 725–34. PMID 12565841.  
  3. ^ "Entrez Gene: GPR124 G protein-coupled receptor 124".  
  4. ^ Yamamoto, Yasunori; Irie Kenji, Asada Masanori, Mino Akihisa, Mandai Kenji, Takai Yoshimi (May. 2004). "Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein". Oncogene (England) 23 (22): 3889–97. doi:10.1038/sj.onc.1207495. ISSN 0950-9232. PMID 15021905.  

Further reading

  • Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.  
  • Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Yamamoto Y, Irie K, Asada M, et al. (2004). "Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein.". Oncogene 23 (22): 3889–97. doi:10.1038/sj.onc.1207495. PMID 15021905.  
  • Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.". Genomics 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.  
  • Vallon M, Essler M (2006). "Proteolytically processed soluble tumor endothelial marker (TEM) 5 mediates endothelial cell survival during angiogenesis by linking integrin alpha(v)beta3 to glycosaminoglycans.". J. Biol. Chem. 281 (45): 34179–88. doi:10.1074/jbc.M605291200. PMID 16982628.  


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