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G protein-coupled receptor 132
Symbols GPR132; G2A; MGC99642
External IDs OMIM606167 MGI1890220 HomoloGene8350 IUPHAR: GPR132 GeneCards: GPR132 Gene
RNA expression pattern
PBB GE GPR132 221140 s at tn.png
More reference expression data
Species Human Mouse
Entrez 29933 56696
Ensembl ENSG00000183484 ENSMUSG00000021298
UniProt Q9UNW8 Q0VBS4
RefSeq (mRNA) NM_013345 NM_019925
RefSeq (protein) NP_037477 NP_064309
Location (UCSC) Chr 14:
104.59 - 104.6 Mb
Chr 12:
113.3 - 113.31 Mb
PubMed search [1] [2]

Probable G-protein coupled receptor 132 is a protein that in humans is encoded by the GPR132 gene.[1][2]

This gene encodes a subfamily member of the G-protein couple receptor (GPCR) superfamily. The encoded protein is a high-affinity receptor for lysophosphatidylcholine (LPC), a major phospholipid component of oxidized low density lipoprotein. This protein may react to LPC levels at sites of inflammation to limit the expansion of tissue-infiltrating cells. A similar protein in mouse is involved in cell cycle progression.[2]

See also


  1. ^ Le LQ, Kabarowski JH, Wong S, Nguyen K, Gambhir SS, Witte ON (Jun 2002). "Positron emission tomography imaging analysis of G2A as a negative modifier of lymphoid leukemogenesis initiated by the BCR-ABL oncogene". Cancer Cell 1 (4): 381-91. PMID 12086852.  
  2. ^ a b "Entrez Gene: GPR132 G protein-coupled receptor 132".  

Further reading

  • Weng Z, Fluckiger AC, Nisitani S, et al. (1998). "A DNA damage and stress inducible G protein-coupled receptor blocks cells in G2/M.". Proc. Natl. Acad. Sci. U.S.A. 95 (21): 12334–9. doi:10.1073/pnas.95.21.12334. PMID 9770487.  
  • Kabarowski JH, Zhu K, Le LQ, et al. (2001). "Lysophosphatidylcholine as a ligand for the immunoregulatory receptor G2A.". Science 293 (5530): 702–5. doi:10.1126/science.1061781. PMID 11474113.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Rikitake Y, Hirata K, Yamashita T, et al. (2002). "Expression of G2A, a receptor for lysophosphatidylcholine, by macrophages in murine, rabbit, and human atherosclerotic plaques.". Arterioscler. Thromb. Vasc. Biol. 22 (12): 2049–53. doi:10.1161/01.ATV.0000040598.18570.54. PMID 12482833.  
  • Lin P, Ye RD (2003). "The lysophospholipid receptor G2A activates a specific combination of G proteins and promotes apoptosis.". J. Biol. Chem. 278 (16): 14379–86. doi:10.1074/jbc.M209101200. PMID 12586833.  
  • Lum H, Qiao J, Walter RJ, et al. (2003). "Inflammatory stress increases receptor for lysophosphatidylcholine in human microvascular endothelial cells.". Am. J. Physiol. Heart Circ. Physiol. 285 (4): H1786–9. doi:10.1152/ajpheart.00359.2003. PMID 12805023.  
  • Murakami N, Yokomizo T, Okuno T, Shimizu T (2004). "G2A is a proton-sensing G-protein-coupled receptor antagonized by lysophosphatidylcholine.". J. Biol. Chem. 279 (41): 42484–91. doi:10.1074/jbc.M406561200. PMID 15280385.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Witte ON, Kabarowski JH, Xu Y, et al. (2005). "Retraction.". Science 307 (5707): 206. doi:10.1126/science.307.5707.206b. PMID 15653487.  
  • Radu CG, Nijagal A, McLaughlin J, et al. (2005). "Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells.". Proc. Natl. Acad. Sci. U.S.A. 102 (5): 1632–7. doi:10.1073/pnas.0409415102. PMID 15665078.  
  • Obinata H, Hattori T, Nakane S, et al. (2006). "Identification of 9-hydroxyoctadecadienoic acid and other oxidized free fatty acids as ligands of the G protein-coupled receptor G2A.". J. Biol. Chem. 280 (49): 40676–83. doi:10.1074/jbc.M507787200. PMID 16236715.  
  • Frasch SC, Zemski-Berry K, Murphy RC, et al. (2007). "Lysophospholipids of different classes mobilize neutrophil secretory vesicles and induce redundant signaling through G2A.". J. Immunol. 178 (10): 6540–8. PMID 17475884.  


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