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G protein-coupled receptor 15
Symbols GPR15; MGC126828; MGC126830
External IDs OMIM601166 MGI1918473 HomoloGene3869 IUPHAR: GPR15 GeneCards: GPR15 Gene
RNA expression pattern
PBB GE GPR15 208524 at tn.png
More reference expression data
Species Human Mouse
Entrez 2838 71223
Ensembl ENSG00000154165 ENSMUSG00000047293
UniProt P49685 n/a
RefSeq (mRNA) NM_005290 XM_001002039
RefSeq (protein) NP_005281 XP_001002039
Location (UCSC) Chr 3:
99.73 - 99.73 Mb
Chr 16:
58.66 - 58.66 Mb
PubMed search [1] [2]

G-protein coupled receptor 15 is a protein that in humans is encoded by the GPR15 gene.[1][2]


  1. ^ Heiber M, Marchese A, Nguyen T, Heng HH, George SR, O'Dowd BF (Feb 1997). "A novel human gene encoding a G-protein-coupled receptor (GPR15) is located on chromosome 3". Genomics 32 (3): 462-5. doi:10.1006/geno.1996.0143. PMID 8838812.  
  2. ^ "Entrez Gene: GPR15 G protein-coupled receptor 15".  

Further reading

  • Cunningham AL, Li S, Juarez J, et al. (2000). "The level of HIV infection of macrophages is determined by interaction of viral and host cell genotypes.". J. Leukoc. Biol. 68 (3): 311–7. PMID 10985245.  
  • Deng HK, Unutmaz D, KewalRamani VN, Littman DR (1997). "Expression cloning of new receptors used by simian and human immunodeficiency viruses.". Nature 388 (6639): 296–300. doi:10.1038/40894. PMID 9230441.  
  • Farzan M, Choe H, Martin K, et al. (1997). "Two orphan seven-transmembrane segment receptors which are expressed in CD4-positive cells support simian immunodeficiency virus infection.". J. Exp. Med. 186 (3): 405–11. doi:10.1084/jem.186.3.405. PMID 9236192.  
  • Clayton F, Kotler DP, Kuwada SK, et al. (2001). "Gp120-induced Bob/GPR15 activation: a possible cause of human immunodeficiency virus enteropathy.". Am. J. Pathol. 159 (5): 1933–9. PMID 11696454.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Croitoru-Lamoury J, Guillemin GJ, Boussin FD, et al. (2003). "Expression of chemokines and their receptors in human and simian astrocytes: evidence for a central role of TNF alpha and IFN gamma in CXCR4 and CCR5 modulation.". Glia 41 (4): 354–70. doi:10.1002/glia.10181. PMID 12555203.  
  • Maresca M, Mahfoud R, Garmy N, et al. (2003). "The virotoxin model of HIV-1 enteropathy: involvement of GPR15/Bob and galactosylceramide in the cytopathic effects induced by HIV-1 gp120 in the HT-29-D4 intestinal cell line.". J. Biomed. Sci. 10 (1): 156–66. doi:10.1159/000068089. PMID 12566994.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Blaak H, Boers PH, Gruters RA, et al. (2005). "CCR5, GPR15, and CXCR6 are major coreceptors of human immunodeficiency virus type 2 variants isolated from individuals with and without plasma viremia.". J. Virol. 79 (3): 1686–700. doi:10.1128/JVI.79.3.1686-1700.2005. PMID 15650194.  
  • Cilliers T, Willey S, Sullivan WM, et al. (2005). "Use of alternate coreceptors on primary cells by two HIV-1 isolates.". Virology 339 (1): 136–44. doi:10.1016/j.virol.2005.05.027. PMID 15992849.  


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