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G protein-coupled receptor 177
Symbols GPR177; MRP; C1orf139; FLJ23091; MGC131760; MGC14878; WLS
External IDs MGI1915401 HomoloGene11779 GeneCards: GPR177 Gene
RNA expression pattern
PBB GE GPR177 221958 s at tn.png
More reference expression data
Species Human Mouse
Entrez 79971 68151
Ensembl ENSG00000116729 ENSMUSG00000028173
UniProt Q5T9L3 Q8CDZ6
RefSeq (mRNA) NM_001002292 NM_026582
RefSeq (protein) NP_001002292 NP_080858
Location (UCSC) Chr 1:
68.34 - 68.47 Mb
Chr 3:
159.78 - 159.87 Mb
PubMed search [1] [2]

G protein-coupled receptor 177 (GPR177), commonly known as Wntless, is a human gene[1] that encodes a receptor for Wnt proteins in Wnt-secreting cells.[2]

Wntless was recently shown to be a cargo for the retromer complex.[2]


Further reading

  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.  
  • Bänziger C, Soldini D, Schütt C, et al. (2006). "Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells.". Cell 125 (3): 509–22. doi:10.1016/j.cell.2006.02.049. PMID 16678095.  
  • Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.  
  • Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.". Oncogene 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  

See also

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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